HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: EPN1 (Q9Y6I3)
Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1)
Gene: EPN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1014 Hs			1 576
+	Hs
		307499 PARP1_HUMAN (1-1014): 0: 1362: 100.00		EPN2_HUMAN (1-566): 6.51e-54: 195: 38.02
+	Hs
		1057063 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Hs
		310090 TNKS1_HUMAN (639-1012): 2.38e-74: 270: 18.53		EPN3_HUMAN (1-571): 3.16e-55: 199: 40.16
+	Hs
		1328936 TNKS2_HUMAN (639-1013): 1.1e-71: 261: 17.86		EPN3_HUMAN (1-571): 3.16e-55: 199: 40.16
+	Hs
		1188580 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		KMT2C_HUMAN (154-571): 9.93e-12: 70.5: 11.88