HitPredict

Interactor 1: UCHL1 (P09936)
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1)
Gene: UCHL1

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	1.00	0.990

Property	Details
Experiments	2532544, 29576527, 28935764, 16169070, 31494268, 33141564, 33719392, 34326324, 34642328, 36114200, 23801757, 27066941, 28338014, 27501351, 33238157, 32865982, 34129829, 19154770, 33583181, 20622874 and 3 others more... 22284438, 20439756, 9521656
Identification Methods	pull down, two hybrid, unspecified method, x-ray crystallography, enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	Peptidase_C12~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 223 Hs			1 685
+	Hs
		476639 UCHL5_HUMAN (2-220): 2.67e-99: 293: 21.68		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475307 UCHL3_HUMAN (2-222): 2.74e-100: 292: 54.43		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476130 BAP1_HUMAN (3-220): 2.36e-78: 250: 22.27		UBC_HUMAN (1-685): 0: 846: 100.00
+	Sc
		477215 UBL1_YEAST (5-219): 2.26e-54: 175: 26.29		UBI4P_YEAST (381-685): 5e-122: 370: 95.74
+	Hs
		456536 UCHL1_HUMAN (1-223): 2.52e-103: 299: 100.00		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Mm
		477047 UCHL1_MOUSE (1-223): 3.97e-102: 296: 95.52		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Rn
		962731 UCHL1_RAT (1-223): 3.97e-102: 296: 95.52		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Mm
		477056 UCHL5_MOUSE (2-220): 9.27e-100: 294: 22.12		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Mm
		477030 UCHL3_MOUSE (2-222): 1.91e-100: 292: 55.31		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Mm
		476730 UCHL4_MOUSE (2-222): 1.2e-96: 283: 53.71		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		456474 UCHL1_HUMAN (1-223): 2.52e-103: 299: 100.00		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		398154 UCHL5_HUMAN (2-220): 2.67e-99: 293: 21.68		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69
+	Hs
		474910 UCHL3_HUMAN (2-222): 2.74e-100: 292: 54.43		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		548107 UCHL3_HUMAN (2-222): 2.74e-100: 292: 54.43		Q5U5U6_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		924096 BAP1_HUMAN (3-220): 2.36e-78: 250: 22.27		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00