HitPredict

Interactor 1: UCHL1 (P09936)
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1)
Gene: UCHL1

Interactor 2: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	23543736
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 223 Hs			1 303
+	Hs
		456499 UCHL1_HUMAN (1-223): 2.52e-103: 299: 100.00		CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22
+	Hs
		414694 UCHL1_HUMAN (1-223): 2.52e-103: 299: 100.00		CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24
+	Hs
		456547 UCHL1_HUMAN (1-223): 2.52e-103: 299: 100.00		CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03
+	Mm
		509494 UCHL1_MOUSE (1-223): 3.97e-102: 296: 95.52		CDK1_MOUSE (3-300): 1.06e-128: 370: 42.24
+	Mm
		673241 UCHL1_MOUSE (1-223): 3.97e-102: 296: 95.52		CDK4_MOUSE (1-299): 5.01e-126: 363: 95.65
+	Hs
		456548 UCHL1_HUMAN (1-223): 2.52e-103: 299: 100.00		CDK5_HUMAN (3-301): 5.52e-124: 357: 43.09
+	Hs
		415011 BAP1_HUMAN (3-220): 2.36e-78: 250: 22.27		CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24