HitPredict

Interactor 1: UCHL1 (P09936)
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1)
Gene: UCHL1

Interactor 2: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	25640309, 16027165
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 223 Hs			1 480
+	Hs
		456507 UCHL1_HUMAN (1-223): 2.52e-103: 299: 100.00		AKT2_HUMAN (1-477): 0: 559: 81.21
+	Hs
		681954 BAP1_HUMAN (3-220): 2.36e-78: 250: 22.27		AKT1_HUMAN (1-480): 0: 586: 100.00
+	Mm
		593491 BAP1_MOUSE (3-220): 2e-78: 251: 22.27		KPCA_MOUSE (14-477): 6.01e-151: 447: 36.05
+	Hs
		1267217 BAP1_HUMAN (3-220): 2.36e-78: 250: 22.27		KS6B2_HUMAN (129-479): 4.6e-147: 430: 42.25
+	Hs
		568746 BAP1_HUMAN (3-220): 2.36e-78: 250: 22.27		KAPCA_HUMAN (138-445): 1.76e-144: 419: 42.53