HitPredict

Interactor 1: FURIN (P09958)
Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE)
Gene: FURIN

Interactor 2: MMP14 (P50281)
Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)
Gene: MMP14

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 0.60 0.650

The method score is based on:

Property Details
Experiments 8804434, 21152186, 20608975
Identification Methods enzymatic study, pull down, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0004175 - endopeptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005796 - Golgi lumen
GO:0005886 - plasma membrane
GO:0016485 - protein processing
and 4 others

more...
Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 794
Hs

1 582
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024