HitPredict

Interactor 1: A0A2R8Y8E0 (A0A2R8Y8E0)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Gene: BRAF

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	14-3-3~C1_1, 14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 807 Hs			1 247
+	Hs
		46558 A0A2R8Y8E0_HUMAN (1-807): 0: 873: 100.00		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		110869 H7C560_HUMAN (1-807): 0: 838: 95.04		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		542849 BRAF_HUMAN (1-804): 0: 832: 94.78		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		542847 BRAF_HUMAN (1-804): 0: 832: 94.78		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		542868 BRAF_HUMAN (1-804): 0: 832: 94.78		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Gg
		982842 BRAF_CHICK (18-804): 0: 806: 90.13		1433E_CHICK (1-244): 2.02e-141: 398: 63.53
+	Gg
		982833 BRAF_CHICK (18-804): 0: 806: 90.13		1433G_CHICK (1-247): 7.26e-140: 393: 99.60
+	Hs
		46556 A0A2R8Y8E0_HUMAN (1-807): 0: 873: 100.00		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Gg
		982837 BRAF_CHICK (18-804): 0: 806: 90.13		Q5ZKJ2_CHICK (1-247): 4.16e-134: 379: 87.45
+	Mm
		655938 BRAF_MOUSE (12-804): 0: 781: 87.55		1433E_MOUSE (1-244): 2.02e-141: 398: 63.53
+	Mm
		655936 BRAF_MOUSE (12-804): 0: 781: 87.55		1433G_MOUSE (1-247): 3.15e-139: 392: 100.00
+	Hs
		110870 H7C560_HUMAN (1-807): 0: 838: 95.04		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		542827 BRAF_HUMAN (1-804): 0: 832: 94.78		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		542857 BRAF_HUMAN (1-804): 0: 832: 94.78		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		542820 BRAF_HUMAN (1-804): 0: 832: 94.78		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Gg
		982838 BRAF_CHICK (18-804): 0: 806: 90.13		1433B_CHICK (2-247): 1.22e-109: 317: 76.21
+	Hs
		542828 BRAF_HUMAN (1-804): 0: 832: 94.78		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Gg
		982836 BRAF_CHICK (18-804): 0: 806: 90.13		1433Z_CHICK (2-245): 4.61e-108: 313: 74.59
+	Gg
		982840 BRAF_CHICK (18-804): 0: 806: 90.13		1433T_CHICK (2-245): 5.56e-106: 308: 71.14
+	Mm
		250867 BRAF_MOUSE (12-804): 0: 781: 87.55		1433S_MOUSE (2-236): 1.38e-95: 281: 65.96