HitPredict

Interactor 1: MBHL (P0ACD8)
Hydrogenase-1 large chain (HYD1) (EC 1.12.99.6) (Membrane-bound hydrogenase 1 large subunit) (NiFe hydrogenase)
Gene: hyaB

Interactor 2: MBHS (P69739)
Hydrogenase-1 small chain (HYD1) (EC 1.12.99.6) (Membrane-bound hydrogenase 1 small subunit) (NiFe hydrogenase)
Gene: hyaA

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.884

The method score is based on:

Property Details
Experiments 26619250, 22431599, 19402753
Identification Methods molecular sieving, pull down, x-ray crystallography, tandem affinity purification
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains NiFe_hyd_SSU_C~NiFeSe_Hases, NiFeSe_Hases~Oxidored_q6
Common GO terms GO:0006113 - fermentation
GO:0008901 - ferredoxin hydrogenase activity
GO:0009055 - electron transfer activity
GO:0009061 - anaerobic respiration
GO:0009267 - cellular response to starvation
and 6 others

more...
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 597
Ec

1 372
+ Ec
+ Nv
+ Nv

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024