HitPredict

Interactor 1: CO4B (P0C0L5)
Complement C4-B (Basic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3) [Cleaved into: Complement C4 beta chain; Complement C4-B alpha chain; C4a anaphylatoxin; C4b-B; C4d-B; Complement C4 gamma chain]
Gene: C4B

Interactor 2: MCP (P15529)
Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46)
Gene: CD46

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8666815
Identification Methods	solid phase assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	A2M~Sushi, A2M_BRD~Sushi, MG2~Sushi, MG4~Sushi, NTR~Sushi, Sushi~TED_complement
Common GO terms	GO:0005615 - extracellular space GO:0005886 - plasma membrane GO:0006958 - complement activation, classical pathway GO:0045087 - innate immune response GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1744 Hs			1 392
+	Hs
		416129 CO4A_HUMAN (1-1744): 0: 2073: 99.43		CO2_HUMAN (4-167): 6.66e-20: 93.8: 20.96
+	Hs
		416130 CO4B_HUMAN (1-1744): 0: 2072: 100.00		CO2_HUMAN (4-167): 6.66e-20: 93.8: 20.96
+	Hs
		469878 CO4A_HUMAN (1-1744): 0: 2073: 99.43		FHR4_HUMAN (7-284): 1.34e-17: 86.5: 17.57
+	Hs
		469908 CO4B_HUMAN (1-1744): 0: 2072: 100.00		FHR4_HUMAN (7-284): 1.34e-17: 86.5: 17.57
+	Hs
		469849 CO4A_HUMAN (1-1744): 0: 2073: 99.43		MASP1_HUMAN (14-166): 2.15e-13: 73.8: 15.85
+	Hs
		469901 CO4B_HUMAN (1-1744): 0: 2072: 100.00		MASP1_HUMAN (14-166): 2.15e-13: 73.8: 15.85
+	Hs
		119683 CO4A_HUMAN (1-1744): 0: 2073: 99.43		MASP2_HUMAN (27-161): 4.85e-12: 69.6: 17.24
+	Hs
		119684 CO4B_HUMAN (1-1744): 0: 2072: 100.00		MASP2_HUMAN (27-161): 4.85e-12: 69.6: 17.24
+	Hs
		344632 CO3_HUMAN (20-1742): 0: 1527: 27.92		MCP_HUMAN (1-392): 1.96e-92: 284: 100.00
+	Mm
		344735 CO3_MOUSE (21-1742): 0: 1567: 27.95		CFAH_MOUSE (147-379): 1.01e-19: 93.5: 16.39
+	Hs
		344636 CO3_HUMAN (20-1742): 0: 1527: 27.92		CR1_HUMAN (1-376): 4.89e-33: 133: 15.06
+	Hs
		344638 CO3_HUMAN (20-1742): 0: 1527: 27.92		CR2_HUMAN (97-351): 2.09e-32: 131: 19.62
+	Hs
		344619 CO3_HUMAN (20-1742): 0: 1527: 27.92		F13B_HUMAN (34-390): 7.98e-31: 126: 16.62
+	Rn
		344734 CO3_RAT (21-1742): 0: 1561: 27.71		Q6MG73_RAT (4-167): 6.61e-18: 87.6: 21.39
+	Hs
		344624 CO3_HUMAN (20-1742): 0: 1527: 27.92		CFAH_HUMAN (1-349): 1.19e-20: 96.2: 18.38
+	Hs
		341566 CO3_HUMAN (20-1742): 0: 1527: 27.92		CFAB_HUMAN (3-158): 8.48e-19: 90.3: 22.01
+	Hs
		344697 CO3_HUMAN (20-1742): 0: 1527: 27.92		FHR4_HUMAN (7-284): 1.34e-17: 86.5: 17.57
+	Hs
		344649 CO3_HUMAN (20-1742): 0: 1527: 27.92		MASP1_HUMAN (14-166): 2.15e-13: 73.8: 15.85
+	Hs
		119680 CO3_HUMAN (20-1742): 0: 1527: 27.92		MASP2_HUMAN (27-161): 4.85e-12: 69.6: 17.24
+	Hs
		344663 CO3_HUMAN (20-1742): 0: 1527: 27.92		FHR1_HUMAN (1-160): 8.47e-09: 58.4: 17.96