HitPredict

Interactor 1: H2AZ (P0C0S5)
Histone H2A.Z (H2A/z)
Gene: H2AZ1

Interactor 2: SMCA1 (P28370)
Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)
Gene: SMARCA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	28242625, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 1054
+	Hs
		555306 H2AX_HUMAN (5-124): 1.08e-54: 169: 61.98		SMCA1_HUMAN (1-1054): 0: 1130: 100.00
+	Hs
		229286 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		SMCA5_HUMAN (32-1051): 0: 1065: 81.86
+	Hs
		229433 H2A2B_HUMAN (5-127): 9.2e-56: 171: 59.68		SMCA5_HUMAN (32-1051): 0: 1065: 81.86
+	Hs
		229279 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		SMCA5_HUMAN (32-1051): 0: 1065: 81.86
+	Hs
		229296 H2AX_HUMAN (5-124): 1.08e-54: 169: 61.98		SMCA5_HUMAN (32-1051): 0: 1065: 81.86
+	Hs
		470021 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		CHD4_HUMAN (29-960): 0: 789: 28.27
+	Hs
		1018640 H2A1H_HUMAN (5-125): 2.98e-55: 170: 61.48		CHD3_HUMAN (31-954): 0: 791: 28.94
+	Hs
		1059717 H2A2B_HUMAN (5-127): 9.2e-56: 171: 59.68		CHD4_HUMAN (29-960): 0: 789: 28.27
+	Hs
		391675 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		CHD3_HUMAN (31-954): 0: 791: 28.94
+	Hs
		1059647 H2A2C_HUMAN (5-127): 3.47e-55: 170: 61.29		CHD4_HUMAN (29-960): 0: 789: 28.27
+	Hs
		1059795 H2A1H_HUMAN (5-125): 2.98e-55: 170: 61.48		CHD4_HUMAN (29-960): 0: 789: 28.27
+	Hs
		391704 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		CHD4_HUMAN (29-960): 0: 789: 28.27
+	Hs
		470170 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		CHD8_HUMAN (2-1011): 0: 769: 27.72
+	Hs
		391915 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		CHD8_HUMAN (2-1011): 0: 769: 27.72
+	Hs
		391728 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		CHD9_HUMAN (2-1019): 0: 741: 26.94
+	Hs
		151474 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		CHD2_HUMAN (21-1047): 0: 732: 29.60
+	Hs
		469971 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		SMCA4_HUMAN (60-913): 0: 686: 31.42
+	Mm
		470232 H2AZ_MOUSE (1-128): 9.79e-62: 186: 100.00		SMCA4_MOUSE (60-836): 0: 663: 35.23
+	Hs
		470077 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		CHD1L_HUMAN (183-755): 2.35e-132: 424: 43.06
+	Hs
		1185203 H2A3_HUMAN (5-125): 5.08e-55: 169: 62.30		CHD1L_HUMAN (183-755): 2.35e-132: 424: 43.06