HitPredict

Interactor 1: H2AZ (P0C0S5)
Histone H2A.Z (H2A/z)
Gene: H2AZ1

Interactor 2: EP400 (Q96L91)
E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein)
Gene: EP400

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	28242625, 33961781, 35271311, 22467210, 24463511
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0000786 - nucleosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 3159
+	Hs
		391846 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		EP400_HUMAN (1-3159): 0: 1399: 100.00
+	Hs
		229286 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		SMCA5_HUMAN (970-1548): 0: 629: 21.71
+	Hs
		469951 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		SMCA1_HUMAN (938-1627): 0: 623: 19.83
+	Hs
		229433 H2A2B_HUMAN (5-127): 9.2e-56: 171: 59.68		SMCA5_HUMAN (970-1548): 0: 629: 21.71
+	Hs
		229279 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		SMCA5_HUMAN (970-1548): 0: 629: 21.71
+	Hs
		229296 H2AX_HUMAN (5-124): 1.08e-54: 169: 61.98		SMCA5_HUMAN (970-1548): 0: 629: 21.71
+	Hs
		470278 H2A1_HUMAN (5-125): 8.23e-55: 169: 61.48		SMCA1_HUMAN (938-1627): 0: 623: 19.83
+	Hs
		555306 H2AX_HUMAN (5-124): 1.08e-54: 169: 61.98		SMCA1_HUMAN (938-1627): 0: 623: 19.83
+	Hs
		391728 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		CHD9_HUMAN (1565-2538): 3.24e-144: 509: 13.41
+	Hs
		470170 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		CHD8_HUMAN (1521-2397): 1.55e-138: 490: 13.07
+	Hs
		391915 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		CHD8_HUMAN (1521-2397): 1.55e-138: 490: 13.07
+	Hs
		555654 H2AX_HUMAN (5-124): 1.08e-54: 169: 61.98		CHD8_HUMAN (1521-2397): 1.55e-138: 490: 13.07
+	Hs
		1087132 H2A2C_HUMAN (5-127): 3.47e-55: 170: 61.29		INO80_HUMAN (1754-2150): 2.56e-83: 307: 25.38
+	Hs
		391964 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		INO80_HUMAN (1754-2150): 2.56e-83: 307: 25.38
+	Hs
		470059 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		SRCAP_HUMAN (2495-3157): 8.1e-17: 90.5: 14.39
+	Mm
		470232 H2AZ_MOUSE (1-128): 9.79e-62: 186: 100.00		SMCA4_MOUSE (2528-2890): 6.78e-09: 64.1: 11.57
+	Hs
		469971 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	At
		1186947 H2AV3_ARATH (1-125): 6.23e-55: 169: 77.60		PIE1_ARATH (1396-1518): 6.2e-13: 77.5: 8.13
+	Hs
		555358 H2AX_HUMAN (5-124): 1.08e-54: 169: 61.98		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Hs
		555359 H2AX_HUMAN (5-124): 1.08e-54: 169: 61.98		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17