HitPredict

Interactor 1: H2A1 (P0C0S8)
Histone H2A type 1 (H2A.1) (Histone H2A/ptl)
Gene: H2AC11

Interactor 2: H4 (P62805)
Histone H4
Gene: H4C1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	33961781, 34349018, 37071682, 24463511
Identification Methods	affinity chromatography technology, cross-linking study, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CENP-T_C~Histone, CENP-T_C~Histone_H2A_C
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 130 Hs			1 103
+	Hs
		594838 H2A1D_HUMAN (1-130): 9.47e-68: 202: 99.23		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917438 H2A2A_HUMAN (1-130): 6.74e-68: 202: 98.46		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917496 H2A3_HUMAN (1-130): 9.27e-68: 202: 97.69		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917699 H2A1C_HUMAN (1-130): 8.04e-68: 202: 98.46		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		391638 H2A1B_HUMAN (1-130): 1.13e-67: 201: 98.46		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917817 H2A1J_HUMAN (1-128): 2.78e-67: 201: 99.22		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917757 H2A1H_HUMAN (1-128): 4.17e-67: 200: 100.00		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917544 H2A2B_HUMAN (1-130): 2.11e-66: 198: 94.62		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917354 H2A2C_HUMAN (1-130): 3.65e-65: 195: 96.92		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		555395 H2AX_HUMAN (1-129): 8.34e-64: 192: 91.47		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Dm
		950379 H2A_DROME (17-125): 8.06e-60: 181: 89.91		H4_DROME (1-103): 4.51e-48: 150: 99.03
+	Sc
		356148 H2A2_YEAST (16-128): 2.5e-59: 180: 80.53		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Sc
		356147 H2A1_YEAST (16-127): 4.04e-53: 165: 81.25		H4_YEAST (18-103): 6.13e-41: 132: 90.70