HitPredict

Interactor 1: LRC4B (P0C192)
Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3)
Gene: Lrrc4b

Interactor 2: DLG4 (Q62108)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	36417873, 36604605
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005102 - signaling receptor binding GO:0005886 - plasma membrane GO:0044300 - cerebellar mossy fiber GO:0051965 - positive regulation of synapse assembly GO:0098839 - postsynaptic density membrane and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 709 Mm			1 724
+	Mm
		1103492 LRFN1_MOUSE (51-635): 8.03e-82: 277: 23.56		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Mm
		1143377 LRFN4_MOUSE (59-530): 1.46e-77: 262: 26.46		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Mm
		1143441 LRRT1_MOUSE (37-397): 2.93e-60: 213: 22.02		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Mm
		1103493 LRFN1_MOUSE (51-635): 8.03e-82: 277: 23.56		DLG1_MOUSE (8-724): 0: 577: 68.93
+	Rn
		677783 LRFN2_RAT (58-439): 3.62e-32: 135: 29.29		DLG4_RAT (1-724): 0: 671: 99.45
+	Mm
		1143368 LRFN2_MOUSE (58-439): 2.01e-31: 133: 29.04		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Mm
		1143410 LRC4C_MOUSE (1-231): 4.29e-31: 131: 17.80		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Rn
		1115172 LRFN2_RAT (58-439): 3.62e-32: 135: 29.29		DLG3_RAT (20-724): 0: 585: 63.94
+	Mm
		936183 LRFN2_MOUSE (58-439): 2.01e-31: 133: 29.04		DLG3_MOUSE (20-724): 0: 585: 63.94
+	Mm
		936185 LRC4C_MOUSE (1-231): 4.29e-31: 131: 17.80		DLG3_MOUSE (20-724): 0: 585: 63.94
+	Mm
		1193431 LRFN2_MOUSE (58-439): 2.01e-31: 133: 29.04		DLG1_MOUSE (8-724): 0: 577: 68.93
+	Rn
		1115171 LRFN2_RAT (58-439): 3.62e-32: 135: 29.29		DLG1_RAT (8-724): 0: 564: 66.98
+	Hs
		1021503 NTRK3_HUMAN (31-486): 7.17e-19: 93.4: 14.67		DLG1_HUMAN (28-724): 0: 576: 72.79
+	Hs
		1162226 LRFN4_HUMAN (59-530): 1.52e-78: 265: 27.50		PALS1_HUMAN (22-196): 1.91e-13: 75.9: 14.21
+	Hs
		1050029 LRIG1_HUMAN (71-688): 1.48e-49: 189: 13.59		SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72
+	Hs
		1050047 LGR4_HUMAN (1-306): 9.84e-45: 174: 24.72		SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72
+	Mm
		1207544 LRC4C_MOUSE (1-231): 4.29e-31: 131: 17.80		DLG2_MOUSE (234-473): 4.91e-17: 87.8: 21.95
+	Hs
		1049964 NTRK3_HUMAN (31-486): 7.17e-19: 93.4: 14.67		SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72
+	Hs
		1081505 NTRK3_HUMAN (31-486): 7.17e-19: 93.4: 14.67		MPP7_HUMAN (51-193): 7.87e-16: 83.2: 16.08