HitPredict

Interactor 1: FBSP1 (P0C2W1)
F-box/SPRY domain-containing protein 1 (F-box only protein 45) (hFbxo45)
Gene: FBXO45

Interactor 2: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.949

The method score is based on:

Property Details
Experiments 27705803, 33961781, 25143387, 29997255, 19398581, 24992930
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains F-box-like~Skp1
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0016567 - protein ubiquitination
GO:0019005 - SCF ubiquitin ligase complex
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
and 2 others

more...
Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 286
Hs

1 163
+ Dm
+ Ce
+ Dm
+ Dm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024