HitPredict

Interactor 1: DC8L2 (P0C7V8)
DDB1- and CUL4-associated factor 8-like protein 2 (WD repeat-containing protein 42C)
Gene: DCAF8L2

Interactor 2: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 35487060
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 631 Hs			1 759
+	Mm
		1111816 DCAF8_MOUSE (2-631): 4.76e-122: 375: 63.23		CUL4A_MOUSE (1-759): 0: 977: 95.13
+	Hs
		1043043 DCAF8_HUMAN (1-631): 8.69e-125: 383: 64.56		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		473597 DC8L2_HUMAN (1-631): 7.02e-134: 407: 100.00		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		1043405 DCAF8_HUMAN (1-631): 8.69e-125: 383: 64.56		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		1043068 WDR82_HUMAN (213-543): 1.04e-63: 214: 20.72		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		1043085 WDR5B_HUMAN (358-627): 6.66e-50: 178: 12.13		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		1043419 WDR82_HUMAN (213-543): 1.04e-63: 214: 20.72		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		1043114 POC1B_HUMAN (106-349): 1.72e-39: 153: 15.66		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		1043102 WDTC1_HUMAN (453-631): 8.39e-38: 151: 31.67		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		1043441 WDR5B_HUMAN (358-627): 6.66e-50: 178: 12.13		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		1043499 FBXW7_HUMAN (118-390): 2.4e-44: 170: 15.94		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		1043469 POC1B_HUMAN (106-349): 1.72e-39: 153: 15.66		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		1043455 WDTC1_HUMAN (453-631): 8.39e-38: 151: 31.67		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Mm
		56799 WDTC1_MOUSE (453-631): 4.21e-37: 149: 31.67		CUL4B_MOUSE (10-759): 0: 927: 82.18
+	Hs
		1041861 WDR82_HUMAN (213-543): 1.04e-63: 214: 20.72		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		197016 PRP4_HUMAN (316-618): 4.25e-45: 169: 10.58		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		1042101 POC1B_HUMAN (106-349): 1.72e-39: 153: 15.66		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		1042031 WDTC1_HUMAN (453-631): 8.39e-38: 151: 31.67		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Mm
		1257398 FBXW7_MOUSE (118-390): 1.2e-44: 171: 15.94		CUL1_MOUSE (59-759): 0: 745: 30.55
+	Hs
		1041133 FBXW7_HUMAN (118-390): 2.4e-44: 170: 15.94		CUL1_HUMAN (59-759): 0: 745: 30.55