HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: UBP5 (P45974)
Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)
Gene: USP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	35235311, 32814053
Identification Methods	cross-linking study, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UBA~ubiquitin, UCH~ubiquitin, ubiquitin~zf-UBP
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 229 Hs			1 858
+	Mm
		476724 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		UBP5_MOUSE (1-858): 0: 844: 98.37
+	Rn
		88803 UBC_RAT (1-181): 2.6e-61: 206: 96.13		D3ZVQ0_RAT (1-858): 0: 845: 98.25
+	Mm
		476806 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		UBP13_MOUSE (2-858): 0: 728: 59.44
+	Rn
		88579 UBC_RAT (1-181): 2.6e-61: 206: 96.13		D3ZDI9_RAT (2-858): 0: 716: 59.33
+	Sc
		477245 UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05		UBP14_YEAST (11-855): 4.13e-125: 397: 26.43
+	Hs
		475123 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17
+	Sc
		477366 UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05		UBP8_YEAST (157-680): 1.03e-88: 291: 13.08
+	Hs
		474982 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		UBP46_HUMAN (293-681): 1.18e-80: 266: 14.90
+	Rn
		88542 UBC_RAT (1-181): 2.6e-61: 206: 96.13		D3ZC84_RAT (289-758): 9.64e-84: 296: 15.63
+	Mm
		476759 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		USP9X_MOUSE (289-758): 1.34e-82: 293: 15.44
+	Mm
		477008 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		UBP12_MOUSE (325-683): 1.38e-82: 271: 16.67
+	Hs
		131635 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		USP9Y_HUMAN (289-780): 1.02e-82: 293: 16.07
+	Mm
		476741 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		UBP46_MOUSE (293-681): 1.18e-80: 266: 14.90
+	Mm
		476865 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		UBP8_MOUSE (270-649): 1.18e-71: 257: 19.34
+	Hs
		64200 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UBP27_HUMAN (262-682): 6.68e-84: 277: 14.69
+	Hs
		259261 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UBP12_HUMAN (325-683): 3.4e-80: 264: 16.94
+	Hs
		271114 Q5U5U6_HUMAN (1-229): 4.07e-98: 286: 100.00		UBP2_HUMAN (700-854): 1.43e-11: 70.1: 16.05
+	Mm
		476898 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		UBP44_MOUSE (175-292): 1.71e-23: 108: 20.34
+	Mm
		476939 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		UBP3_MOUSE (702-853): 5.06e-15: 80.8: 16.35
+	Rn
		1137288 UBC_RAT (1-181): 2.6e-61: 206: 96.13		UBP2_RAT (700-854): 1.81e-11: 69.7: 16.05