HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	26592444, 35235311
Identification Methods	enzymatic study, cross-linking study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UBA~ubiquitin, UQ_con~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 229 Hs			1 200
+	Hs
		475249 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72
+	Hs
		474984 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06
+	Dm
		639414 Q9W418_DROME (1-228): 2.1e-92: 282: 100.00		UBCD1_DROME (4-154): 2.12e-74: 222: 41.72
+	Hs
		1137415 Q5U5U6_HUMAN (1-229): 4.07e-98: 286: 100.00		UB2E3_HUMAN (3-153): 8.99e-68: 207: 40.40
+	Hs
		475124 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		UB2E3_HUMAN (3-153): 8.99e-68: 207: 40.40
+	Hs
		474958 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		UBE2A_HUMAN (1-151): 4.98e-67: 203: 30.46
+	Sc
		477103 UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05		UBC4_YEAST (1-153): 6.39e-73: 218: 41.83
+	Mm
		476738 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		UBE2K_MOUSE (1-200): 1.35e-82: 245: 100.00
+	Rn
		88580 UBC_RAT (1-181): 2.6e-61: 206: 96.13		UB2D1_RAT (4-154): 1.87e-75: 225: 39.74
+	Sc
		477123 UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05		UBC1_YEAST (6-153): 2.31e-48: 158: 50.34
+	Hs
		475551 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00
+	Mm
		476737 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		UB2D3_MOUSE (4-154): 1.49e-73: 220: 39.74
+	Dr
		94560 F1QHN6_DANRE (1-228): 3.12e-92: 282: 100.00		Q7T3F3_DANRE (43-154): 5.67e-39: 132: 57.14
+	Hs
		475501 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74
+	Hs
		475550 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UB2D3_HUMAN (4-154): 1.49e-73: 220: 39.74
+	Hs
		475485 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UBE2A_HUMAN (1-151): 4.98e-67: 203: 30.46
+	Hs
		475504 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UB2E1_HUMAN (3-153): 1.87e-66: 203: 39.74
+	Mm
		476739 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		UBE2N_MOUSE (27-153): 1.06e-37: 129: 51.97
+	Rn
		1144263 UBC_RAT (1-181): 2.6e-61: 206: 96.13		UBE2N_RAT (27-153): 8.13e-38: 129: 51.97
+	Hs
		475552 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UBE2N_HUMAN (27-153): 1.06e-37: 129: 51.97