HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: UB2E3 (Q969T4)
Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3)
Gene: UBE2E3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	UQ_con~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 229 Hs			1 207
+	Hs
		1137415 Q5U5U6_HUMAN (1-229): 4.07e-98: 286: 100.00		UB2E3_HUMAN (1-207): 5.71e-90: 264: 100.00
+	Hs
		475249 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		UB2D4_HUMAN (61-206): 1.19e-82: 243: 63.01
+	Hs
		474984 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		UB2D2_HUMAN (61-206): 2.03e-82: 242: 65.07
+	Dm
		639414 Q9W418_DROME (1-228): 2.1e-92: 282: 100.00		UBCD1_DROME (61-206): 9.93e-82: 241: 64.38
+	Sc
		477103 UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05		UBC4_YEAST (60-206): 2.11e-80: 237: 63.95
+	Hs
		474958 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		UBE2A_HUMAN (59-204): 1.17e-69: 210: 35.62
+	Dr
		94560 F1QHN6_DANRE (1-228): 3.12e-92: 282: 100.00		Q7T3F3_DANRE (59-206): 2.34e-70: 212: 44.60
+	Hs
		476155 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UB2E3_HUMAN (1-207): 5.71e-90: 264: 100.00
+	Rn
		88580 UBC_RAT (1-181): 2.6e-61: 206: 96.13		UB2D1_RAT (61-206): 9.93e-82: 241: 61.64
+	Mm
		476737 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		UB2D3_MOUSE (61-206): 1.1e-80: 238: 64.38
+	Hs
		475586 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UB2D2_HUMAN (61-206): 2.03e-82: 242: 65.07
+	Hs
		475501 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UB2D1_HUMAN (61-206): 9.93e-82: 241: 61.64
+	Hs
		475550 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	Rn
		1144263 UBC_RAT (1-181): 2.6e-61: 206: 96.13		UBE2N_RAT (59-206): 1.53e-70: 213: 44.60
+	Hs
		475504 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UB2E1_HUMAN (35-207): 2.62e-79: 236: 87.36
+	Mm
		476739 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		UBE2N_MOUSE (59-206): 3.58e-69: 209: 45.27
+	Sc
		477372 UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05		UBC13_YEAST (59-206): 1.89e-37: 129: 47.30
+	Hs
		475485 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UBE2A_HUMAN (59-204): 1.17e-69: 210: 35.62
+	Hs
		475552 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UBE2N_HUMAN (59-206): 3.58e-69: 209: 45.27
+	Hs
		475597 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UBE2B_HUMAN (59-204): 8.05e-69: 209: 36.30