HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0010008 - endosome membrane GO:0031398 - positive regulation of protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 229 Hs			1 522
+	Hs
		475011 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Rn
		78208 UBC_RAT (1-181): 2.6e-61: 206: 96.13		B5DFH7_RAT (40-500): 4.24e-100: 312: 25.81
+	Hs
		475013 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Hs
		475684 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Mm
		476826 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		TRAF4_MOUSE (54-500): 6.41e-90: 285: 25.43
+	Rn
		88507 UBC_RAT (1-181): 2.6e-61: 206: 96.13		D3Z9G0_RAT (20-501): 1.11e-86: 280: 22.40
+	Hs
		475134 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		TRI11_HUMAN (59-404): 1.13e-49: 179: 12.75
+	Hs
		129527 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		TRAF5_HUMAN (43-500): 4.95e-87: 280: 25.23
+	Mm
		476671 UBB_MOUSE (1-228): 1.3e-95: 283: 100.00		RO52_MOUSE (51-403): 1.44e-45: 167: 14.17
+	Hs
		475177 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11
+	Hs
		475691 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Mm
		476831 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		RO52_MOUSE (51-403): 1.44e-45: 167: 14.17
+	Hs
		475125 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		RN166_HUMAN (61-222): 7.37e-16: 79.1: 22.94
+	Hs
		475753 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		475328 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		475297 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		475680 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		TRI26_HUMAN (61-410): 2.85e-38: 149: 14.59
+	Hs
		475842 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		RN151_HUMAN (54-204): 2.32e-33: 128: 28.03
+	Hs
		476160 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		RN166_HUMAN (61-222): 7.37e-16: 79.1: 22.94
+	Hs
		476188 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		RN125_HUMAN (62-193): 1.59e-11: 66: 25.83