HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	28514442, 33961781, 14743216
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CC2-LZ~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 229 Hs			1 419
+	Hs
		475130 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Mm
		291775 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		NEMO_MOUSE (1-419): 3e-53: 184: 86.64
+	Hs
		476660 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Rn
		1144239 UBC_RAT (1-181): 2.6e-61: 206: 96.13		OPTN_RAT (8-418): 1.4e-33: 134: 25.54
+	Mm
		477062 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		ITSN1_MOUSE (18-402): 2.09e-31: 129: 13.33
+	Hs
		476176 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Mm
		476960 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		MYO5A_MOUSE (38-342): 1.6e-27: 117: 14.33
+	Hs
		475816 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Hs
		924113 RS27A_HUMAN (153-228): 1.76e-44: 147: 100.00		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Mm
		476930 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		MYH9_MOUSE (18-363): 2.99e-10: 64.6: 13.75
+	Hs
		475417 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		475291 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		MYH1_HUMAN (33-391): 2.48e-10: 65: 11.75
+	Hs
		398149 ISG15_HUMAN (3-154): 1.46e-26: 102: 32.26		MYO5A_HUMAN (38-342): 1.7e-24: 108: 14.65
+	Hs
		397813 ISG15_HUMAN (3-154): 1.46e-26: 102: 32.26		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		397814 ISG15_HUMAN (3-154): 1.46e-26: 102: 32.26		MYH10_HUMAN (27-387): 1.16e-10: 65.8: 14.09
+	Hs
		398052 ISG15_HUMAN (3-154): 1.46e-26: 102: 32.26		MY18A_HUMAN (10-390): 4.23e-09: 60.8: 15.89