HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	27182664, 23314748
Identification Methods	proximity labelling technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031625 - ubiquitin protein ligase binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 654
+	Hs
		475281 UBC_HUMAN (1-685): 0: 846: 100.00		HSP7C_HUMAN (26-637): 0: 916: 66.02
+	At
		1092279 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		HSP7E_ARATH (24-649): 0: 908: 63.23
+	Sc
		477107 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		BIP_YEAST (22-638): 0: 798: 68.82
+	At
		1092137 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		BIP1_ARATH (12-635): 0: 838: 70.45
+	Hs
		501951 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		BIP_HUMAN (19-654): 0: 914: 100.00
+	Rn
		926182 UBC_RAT (1-108): 1.27e-29: 127: 90.74		HSP7C_RAT (26-637): 0: 916: 66.02
+	Hs
		397742 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		HSP7C_HUMAN (26-637): 0: 916: 66.02
+	Hs
		474905 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		HSP7C_HUMAN (26-637): 0: 916: 66.02
+	Hs
		564081 OASL_HUMAN (1-153): 6.51e-17: 86.3: 29.11		HSP76_HUMAN (25-635): 0: 915: 62.54