HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	36807144, 23455675
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 475
+	Hs
		476418 UBC_HUMAN (1-685): 0: 846: 100.00		TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32
+	Hs
		475297 UBC_HUMAN (1-685): 0: 846: 100.00		TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17
+	Hs
		476635 UBC_HUMAN (1-685): 0: 846: 100.00		TRI17_HUMAN (1-471): 6.2e-124: 371: 35.39
+	Hs
		476330 UBC_HUMAN (1-685): 0: 846: 100.00		TRIM5_HUMAN (1-466): 9.08e-121: 363: 40.04
+	Xl
		1186351 Q7SY79_XENLA (77-685): 0: 744: 99.84		NF7B_XENLA (9-464): 2.09e-129: 390: 31.57
+	Hs
		475680 UBC_HUMAN (1-685): 0: 846: 100.00		TRI26_HUMAN (1-354): 6.86e-55: 193: 34.73
+	Mm
		476671 UBB_MOUSE (457-685): 2.3e-86: 275: 99.56		RO52_MOUSE (3-467): 1.33e-154: 449: 69.68
+	Mm
		924236 RS27A_MOUSE (609-684): 9.1e-41: 147: 100.00		RO52_MOUSE (3-467): 1.33e-154: 449: 69.68
+	Mm
		476831 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RO52_MOUSE (3-467): 1.33e-154: 449: 69.68
+	Hs
		475134 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53
+	Hs
		475177 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		TRIM5_HUMAN (1-466): 9.08e-121: 363: 40.04