HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	18596201, 23851457, 26548852, 27609087, 28319114, 17679095, 15273720, 15117950, 14661060
Identification Methods	pull down, x-ray crystallography, enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	Cbl_N3~ubiquitin, UBA~ubiquitin, ubiquitin~zf-C3HC4
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016567 - protein ubiquitination
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 906
+	Hs
		475700 UBC_HUMAN (1-685): 0: 846: 100.00		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		476560 UBC_HUMAN (1-685): 0: 846: 100.00		CBLC_HUMAN (42-504): 0: 620: 42.07
+	Hs
		610336 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		CBL_HUMAN (1-906): 0: 917: 100.00
+	Rn
		88778 UBC_RAT (1-108): 1.27e-29: 127: 90.74		D3ZV15_RAT (1-883): 0: 833: 89.00
+	Hs
		475943 UBC_HUMAN (1-685): 0: 846: 100.00		OTOG_HUMAN (405-893): 1.88e-23: 109: 12.85
+	Mm
		476784 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		CBLB_MOUSE (23-901): 0: 791: 45.98
+	At
		1092118 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		Q9LIE8_ARATH (544-906): 4.9e-10: 65.7: 9.84
+	At
		1092229 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		SC24C_ARATH (428-680): 6e-10: 65.3: 13.33
+	Rn
		1144063 UBC_RAT (1-108): 1.27e-29: 127: 90.74		SYNJ1_RAT (403-806): 2.87e-09: 63.4: 10.05