HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: PML (P29590)
Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19)
Gene: PML

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	34795231
Identification Methods	protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 882
+	Hs
		475704 UBC_HUMAN (1-685): 0: 846: 100.00		TIF1B_HUMAN (7-593): 6.89e-69: 247: 13.97
+	Hs
		476330 UBC_HUMAN (1-685): 0: 846: 100.00		TRIM5_HUMAN (44-459): 3.78e-58: 209: 12.33
+	Hs
		175634 UBC_HUMAN (1-685): 0: 846: 100.00		TRI18_HUMAN (48-411): 5.87e-56: 207: 14.22
+	Hs
		476418 UBC_HUMAN (1-685): 0: 846: 100.00		TRI39_HUMAN (48-434): 3.1e-57: 207: 11.37
+	Hs
		668577 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		PML_HUMAN (1-882): 0: 902: 100.00
+	Hs
		475328 UBC_HUMAN (1-685): 0: 846: 100.00		RO52_HUMAN (44-414): 8.03e-56: 202: 13.46
+	Hs
		475753 UBC_HUMAN (1-685): 0: 846: 100.00		TRI25_HUMAN (42-366): 2.13e-54: 201: 16.67
+	Hs
		475680 UBC_HUMAN (1-685): 0: 846: 100.00		TRI26_HUMAN (45-399): 8.61e-52: 192: 12.87
+	Mm
		476823 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		PML_MOUSE (3-864): 0: 860: 69.34
+	Xl
		1186351 Q7SY79_XENLA (77-685): 0: 744: 99.84		NF7B_XENLA (7-419): 2.41e-53: 198: 11.01
+	Hs
		476427 UBC_HUMAN (1-685): 0: 846: 100.00		TRI36_HUMAN (55-384): 5.81e-17: 87.9: 18.51
+	Dr
		91588 F1QHN6_DANRE (229-685): 0: 555: 99.78		E7F1U3_DANRE (39-580): 1.17e-55: 207: 15.05
+	Mm
		476671 UBB_MOUSE (457-685): 2.3e-86: 275: 99.56		RO52_MOUSE (39-416): 2.2e-52: 192: 12.95
+	Hs
		923976 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TIF1B_HUMAN (7-593): 6.89e-69: 247: 13.97
+	Hs
		170323 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TIF1A_HUMAN (27-546): 1.94e-62: 231: 16.49
+	Hs
		923989 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TRI25_HUMAN (42-366): 2.13e-54: 201: 16.67
+	Mm
		924236 RS27A_MOUSE (609-684): 9.1e-41: 147: 100.00		RO52_MOUSE (39-416): 2.2e-52: 192: 12.95
+	Rn
		88684 UBC_RAT (1-108): 1.27e-29: 127: 90.74		TRIM2_RAT (36-580): 2.82e-56: 209: 13.25
+	Rn
		139629 UBC_RAT (1-108): 1.27e-29: 127: 90.74		TIF1B_RAT (46-593): 3.78e-55: 207: 13.37
+	Mm
		476831 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RO52_MOUSE (39-416): 2.2e-52: 192: 12.95