HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: MP2K2 (P36507)
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
Gene: MAP2K2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27182664
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 400
+	Hs
		475390 UBC_HUMAN (1-685): 0: 846: 100.00		AKT1_HUMAN (43-351): 3.37e-124: 369: 20.12
+	Hs
		414696 UBC_HUMAN (1-685): 0: 846: 100.00		CDK1_HUMAN (69-375): 8.1e-111: 328: 24.76
+	Hs
		475699 UBC_HUMAN (1-685): 0: 846: 100.00		MP2K5_HUMAN (8-395): 7.03e-103: 313: 36.46
+	Hs
		475462 UBC_HUMAN (1-685): 0: 846: 100.00		MP2K4_HUMAN (2-396): 1.01e-100: 306: 32.52
+	At
		1091641 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		KIN10_ARATH (71-352): 3.12e-128: 380: 21.88
+	At
		955189 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		KIN11_ARATH (71-344): 2.46e-124: 370: 24.10
+	At
		1092272 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		M2K2_ARATH (50-386): 4.33e-119: 351: 35.69
+	Hs
		681773 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		AKT1_HUMAN (43-351): 3.37e-124: 369: 20.12
+	Hs
		625332 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16
+	Rn
		734877 UBC_RAT (1-108): 1.27e-29: 127: 90.74		MP2K2_RAT (1-400): 2.42e-122: 361: 94.00
+	Hs
		474936 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		AKT2_HUMAN (31-365): 1.76e-125: 372: 20.95
+	Hs
		474935 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		AKT1_HUMAN (43-351): 3.37e-124: 369: 20.12
+	Hs
		474923 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		KAPCG_HUMAN (32-368): 1.73e-122: 360: 21.63
+	Hs
		397911 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		CDK3_HUMAN (69-374): 1.36e-113: 335: 23.64
+	Hs
		475012 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		STK4_HUMAN (41-377): 2.43e-109: 331: 28.74