HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBP8 (P40818)
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)
Gene: USP8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	29576527, 33141564, 38803224, 17711858, 23287719, 25527291, 25485838, 27501351, 34129829, 22195557
Identification Methods	pull down, affinity chromatography technology, enzymatic study, x-ray crystallography, unspecified method
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	UCH~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0010008 - endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 1118
+	Hs
		271022 UBC_HUMAN (1-685): 0: 846: 100.00		UBP2_HUMAN (527-1111): 7.7e-120: 384: 29.62
+	Hs
		476658 UBC_HUMAN (1-685): 0: 846: 100.00		UBP3_HUMAN (628-1113): 3.22e-115: 369: 25.05
+	Hs
		476579 UBC_HUMAN (1-685): 0: 846: 100.00		UBP22_HUMAN (744-1109): 3.1e-111: 358: 27.72
+	Hs
		475566 UBC_HUMAN (1-685): 0: 846: 100.00		UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22
+	Hs
		64200 UBC_HUMAN (1-685): 0: 846: 100.00		UBP27_HUMAN (744-1109): 3.62e-106: 341: 26.80
+	Hs
		475765 UBC_HUMAN (1-685): 0: 846: 100.00		UBP10_HUMAN (388-1110): 2.96e-101: 340: 17.99
+	Hs
		259261 UBC_HUMAN (1-685): 0: 846: 100.00		UBP12_HUMAN (767-1110): 2.83e-106: 339: 27.70
+	Hs
		476545 UBC_HUMAN (1-685): 0: 846: 100.00		UBP21_HUMAN (605-1111): 9.13e-98: 323: 26.08
+	Hs
		475932 UBC_HUMAN (1-685): 0: 846: 100.00		U17L2_HUMAN (776-1111): 3.18e-93: 310: 26.71
+	Dm
		477538 UBIQP_DROME (1-610): 0: 752: 99.84		NOT_DROME (724-1108): 1.56e-106: 344: 25.95
+	Hs
		476624 UBC_HUMAN (1-685): 0: 846: 100.00		UBP15_HUMAN (964-1106): 1.96e-34: 145: 49.65
+	Hs
		475502 UBC_HUMAN (1-685): 0: 846: 100.00		UBP11_HUMAN (964-1106): 7.58e-34: 143: 44.90
+	Hs
		475693 UBC_HUMAN (1-685): 0: 846: 100.00		UBP4_HUMAN (964-1106): 5.42e-33: 140: 44.06
+	Hs
		301354 UBC_HUMAN (1-685): 0: 846: 100.00		UBP19_HUMAN (887-1106): 1.35e-27: 123: 34.91
+	Hs
		476067 UBC_HUMAN (1-685): 0: 846: 100.00		UBP32_HUMAN (957-1042): 1.54e-14: 80.9: 42.53
+	Hs
		475403 UBC_HUMAN (1-685): 0: 846: 100.00		UBP6_HUMAN (957-1042): 8.36e-11: 68.6: 37.21
+	At
		1210479 UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80		UBP15_ARATH (536-1115): 4.66e-98: 334: 18.98
+	Sc
		477294 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP5_YEAST (611-1109): 5.13e-103: 345: 25.33
+	Sc
		477366 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP8_YEAST (736-1107): 2.66e-97: 319: 26.08
+	At
		1092065 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBP15_ARATH (536-1115): 4.66e-98: 334: 18.98