HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: KPCI (P41743)
Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)
Gene: PRKCI

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	28190767, 38803224
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 596
+	Hs
		475653 UBC_HUMAN (1-685): 0: 846: 100.00		KPCZ_HUMAN (15-596): 0: 631: 70.34
+	Hs
		475390 UBC_HUMAN (1-685): 0: 846: 100.00		AKT1_HUMAN (181-586): 1.34e-151: 446: 37.86
+	Hs
		475345 UBC_HUMAN (1-685): 0: 846: 100.00		KS6B1_HUMAN (215-594): 1.3e-145: 432: 35.94
+	Hs
		408535 UBC_HUMAN (1-685): 0: 846: 100.00		KPCB_HUMAN (111-229): 6.31e-18: 89.6: 21.28
+	Hs
		475314 UBC_HUMAN (1-685): 0: 846: 100.00		KPCA_HUMAN (111-223): 4.34e-17: 86.9: 24.37
+	Mm
		476830 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		KPCI_MOUSE (1-596): 0: 700: 98.32
+	Hs
		923962 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		KPCE_HUMAN (43-590): 1.72e-177: 521: 36.23
+	Rn
		448410 UBC_RAT (1-108): 1.27e-29: 127: 90.74		KPCD_RAT (93-587): 4.48e-177: 518: 35.74
+	Rn
		448416 UBC_RAT (1-108): 1.27e-29: 127: 90.74		KPCE_RAT (43-590): 2.47e-175: 516: 35.57
+	Hs
		681773 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		AKT1_HUMAN (181-586): 1.34e-151: 446: 37.86
+	Hs
		474936 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		AKT2_HUMAN (187-586): 9.51e-152: 447: 39.36
+	Hs
		474935 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		AKT1_HUMAN (181-586): 1.34e-151: 446: 37.86
+	Rn
		934619 UBC_RAT (1-108): 1.27e-29: 127: 90.74		KPCB_RAT (111-229): 6.26e-18: 89.6: 21.28
+	Rn
		930581 UBC_RAT (1-108): 1.27e-29: 127: 90.74		KPCG_RAT (126-190): 1.85e-12: 72.4: 43.08
+	Hs
		408534 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		KPCB_HUMAN (111-229): 6.31e-18: 89.6: 21.28