HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBP5 (P45974)
Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)
Gene: USP5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	1.00	0.994

Property	Details
Experiments	16564012, 24424410, 25970461, 27066941, 26876099, 27848959, 27613037, 31663737, 31951392, 24681967, 17692280, 18601651, 18482987, 34648286, 22216260, 20622874, 19373254, 8841133, 16007098, 23287719 and 14 others more... 28190767, 29576527, 31699778, 23563141, 33141564, 17980597, 34642328, 36114200, 38803224, 22428841, 19285159, 22878415, 23314748, 17550899
Identification Methods	pull down, x-ray crystallography, enzymatic study, unspecified method, affinity chromatography technology, protein array
Interaction Type	direct interaction, association, physical association, deubiquitination reaction

Property	Details
Interacting Pfam domains	UBA~ubiquitin, UCH~ubiquitin, ubiquitin~zf-UBP
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 858
+	Hs
		476145 UBC_HUMAN (1-685): 0: 846: 100.00		UBP13_HUMAN (2-858): 0: 721: 59.47
+	Hs
		476579 UBC_HUMAN (1-685): 0: 846: 100.00		UBP22_HUMAN (139-682): 5.21e-111: 352: 14.11
+	Hs
		476400 UBC_HUMAN (1-685): 0: 846: 100.00		UBP42_HUMAN (264-807): 5.1e-86: 301: 11.96
+	Hs
		476146 UBC_HUMAN (1-685): 0: 846: 100.00		USP9X_HUMAN (289-758): 2.24e-84: 298: 16.20
+	Hs
		476493 UBC_HUMAN (1-685): 0: 846: 100.00		UBP36_HUMAN (250-817): 9.73e-85: 295: 13.61
+	Hs
		131635 UBC_HUMAN (1-685): 0: 846: 100.00		USP9Y_HUMAN (289-780): 1.02e-82: 293: 16.07
+	Hs
		476147 UBC_HUMAN (1-685): 0: 846: 100.00		UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17
+	Hs
		64200 UBC_HUMAN (1-685): 0: 846: 100.00		UBP27_HUMAN (262-682): 6.68e-84: 277: 14.69
+	Hs
		475566 UBC_HUMAN (1-685): 0: 846: 100.00		UBP46_HUMAN (293-681): 1.18e-80: 266: 14.90
+	Hs
		259261 UBC_HUMAN (1-685): 0: 846: 100.00		UBP12_HUMAN (325-683): 3.4e-80: 264: 16.94
+	Hs
		475440 UBC_HUMAN (1-685): 0: 846: 100.00		UBP8_HUMAN (282-649): 3.4e-71: 256: 19.16
+	Dm
		477538 UBIQP_DROME (1-610): 0: 752: 99.84		NOT_DROME (197-682): 6.43e-82: 273: 14.12
+	Hs
		476545 UBC_HUMAN (1-685): 0: 846: 100.00		UBP21_HUMAN (319-594): 6.55e-24: 109: 22.37
+	Hs
		476097 UBC_HUMAN (1-685): 0: 846: 100.00		UBP33_HUMAN (174-457): 8.74e-23: 106: 21.60
+	Hs
		476658 UBC_HUMAN (1-685): 0: 846: 100.00		UBP3_HUMAN (702-853): 3.54e-15: 81.2: 16.35
+	Hs
		271022 UBC_HUMAN (1-685): 0: 846: 100.00		UBP2_HUMAN (700-854): 1.43e-11: 70.1: 16.05
+	Hs
		475932 UBC_HUMAN (1-685): 0: 846: 100.00		U17L2_HUMAN (623-857): 2.5e-09: 62.7: 13.87
+	At
		1091780 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBP14_ARATH (7-856): 0: 603: 46.68
+	Sc
		477245 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP14_YEAST (11-855): 4.13e-125: 397: 26.43
+	Sc
		477366 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP8_YEAST (157-680): 1.03e-88: 291: 13.08