HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH3_1~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031625 - ubiquitin protein ligase binding GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 304
+	Hs
		475936 UBC_HUMAN (1-685): 0: 846: 100.00		DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35
+	Hs
		475592 UBC_HUMAN (1-685): 0: 846: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		476483 UBC_HUMAN (1-685): 0: 846: 100.00		ITSN2_HUMAN (189-304): 5.82e-12: 68.3: 11.86
+	Hs
		476640 UBC_HUMAN (1-685): 0: 846: 100.00		CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12
+	Hs
		208981 UBC_HUMAN (1-685): 0: 846: 100.00		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		475816 UBC_HUMAN (1-685): 0: 846: 100.00		ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87
+	Hs
		476167 UBC_HUMAN (1-685): 0: 846: 100.00		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Hs
		923946 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Rn
		924996 UBC_RAT (1-108): 1.27e-29: 127: 90.74		GRB2_RAT (135-297): 2.78e-25: 102: 15.67
+	Hs
		557653 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		474986 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Mm
		70590 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		B2RR82_MOUSE (9-199): 3.92e-13: 72: 17.50
+	Mm
		477062 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		ITSN1_MOUSE (143-302): 6.55e-13: 71.4: 10.98