HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: BRCC3 (P46736)
Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)
Gene: BRCC3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.965

Property	Details
Experiments	28190767, 34642328, 35938958, 36114200, 38803224, 19261749, 19202061, 19214193
Identification Methods	pull down, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	JAB~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 316
+	Hs
		130705 UBC_HUMAN (1-685): 0: 846: 100.00		PSDE_HUMAN (6-309): 7.58e-75: 234: 21.47
+	Hs
		476142 UBC_HUMAN (1-685): 0: 846: 100.00		CSN5_HUMAN (13-228): 6.32e-67: 214: 20.64
+	Sc
		477336 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		RPN11_YEAST (7-267): 4.22e-68: 216: 19.03
+	Sc
		477501 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		CSN5_YEAST (6-297): 2.13e-49: 172: 15.31
+	At
		1092172 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		PSDE_ARATH (6-310): 3.47e-76: 237: 21.73
+	Hs
		474952 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		BRCC3_HUMAN (13-316): 6.26e-139: 397: 100.00
+	Mm
		476703 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		BRCC3_MOUSE (13-316): 3.84e-129: 371: 89.15
+	At
		1091793 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		CSN5A_ARATH (9-214): 8.6e-70: 222: 22.12
+	Hs
		130837 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		PSDE_HUMAN (6-309): 7.58e-75: 234: 21.47
+	Mm
		192886 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		PSDE_MOUSE (6-309): 7.58e-75: 234: 21.47
+	Hs
		130693 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		PSDE_HUMAN (6-309): 7.58e-75: 234: 21.47
+	Hs
		130704 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		PSDE_HUMAN (6-309): 7.58e-75: 234: 21.47
+	Mm
		193512 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		CSN5_MOUSE (13-228): 5.32e-67: 214: 20.64