HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UB2E1 (P51965)
Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1)
Gene: UBE2E1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	34642328
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 193
+	Hs
		476218 UBC_HUMAN (1-685): 0: 846: 100.00		UB2E2_HUMAN (4-193): 2.5e-84: 249: 81.96
+	Hs
		476604 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D4_HUMAN (47-192): 2.38e-81: 239: 63.01
+	Hs
		475586 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D2_HUMAN (47-192): 8.03e-81: 238: 64.38
+	Hs
		475501 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D1_HUMAN (47-192): 3.02e-80: 237: 61.64
+	Hs
		476155 UBC_HUMAN (1-685): 0: 846: 100.00		UB2E3_HUMAN (3-193): 1.26e-78: 235: 77.49
+	Hs
		475550 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D3_HUMAN (47-192): 2.56e-79: 234: 63.70
+	Hs
		475552 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2N_HUMAN (45-192): 8.9e-75: 223: 45.95
+	Hs
		475485 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2A_HUMAN (44-190): 1.1e-70: 212: 36.74
+	Hs
		475597 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2B_HUMAN (44-190): 1.31e-69: 210: 36.05
+	Xl
		919927 Q7SY79_XENLA (77-685): 0: 744: 99.84		UB2D2_XENLA (47-192): 8.03e-81: 238: 64.38
+	Dm
		639414 Q9W418_DROME (229-685): 0: 557: 99.78		UBCD1_DROME (47-192): 2.56e-80: 237: 64.38
+	Dr
		94560 F1QHN6_DANRE (229-685): 0: 555: 99.78		Q7T3F3_DANRE (45-192): 4.31e-74: 221: 45.27
+	Sc
		477103 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC4_YEAST (46-192): 1.28e-79: 235: 63.95
+	At
		715116 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC8_ARATH (47-192): 7.1e-80: 235: 62.33
+	At
		715132 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC9_ARATH (47-192): 6.56e-79: 233: 60.96
+	At
		715147 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC10_ARATH (47-192): 6.49e-79: 233: 60.96
+	At
		715157 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC11_ARATH (47-192): 7.73e-79: 233: 63.01
+	Sc
		477372 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC13_YEAST (45-192): 6.73e-38: 129: 46.62
+	At
		790155 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC2_ARATH (44-190): 1.7e-71: 215: 36.05
+	At
		639385 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC1_ARATH (44-190): 2.19e-71: 214: 36.74