HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	38803224, 15327770, 22184250
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 501
+	Hs
		129527 UBC_HUMAN (1-685): 0: 846: 100.00		TRAF5_HUMAN (7-501): 1.93e-115: 353: 30.90
+	Hs
		476627 UBC_HUMAN (1-685): 0: 846: 100.00		TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08
+	Hs
		476299 UBC_HUMAN (1-685): 0: 846: 100.00		TRAF4_HUMAN (17-498): 1.52e-94: 296: 29.12
+	Hs
		475691 UBC_HUMAN (1-685): 0: 846: 100.00		TRAF1_HUMAN (130-499): 1.15e-88: 279: 37.44
+	Hs
		475328 UBC_HUMAN (1-685): 0: 846: 100.00		RO52_HUMAN (28-368): 2.44e-56: 196: 12.68
+	Hs
		476418 UBC_HUMAN (1-685): 0: 846: 100.00		TRI39_HUMAN (26-347): 3.57e-42: 159: 14.16
+	Hs
		476330 UBC_HUMAN (1-685): 0: 846: 100.00		TRIM5_HUMAN (22-324): 8.17e-41: 155: 14.52
+	Hs
		475753 UBC_HUMAN (1-685): 0: 846: 100.00		TRI25_HUMAN (27-347): 1.26e-39: 153: 12.95
+	Hs
		475842 UBC_HUMAN (1-685): 0: 846: 100.00		RN151_HUMAN (17-179): 7.22e-34: 130: 24.41
+	Hs
		476188 UBC_HUMAN (1-685): 0: 846: 100.00		RN125_HUMAN (32-167): 6.6e-34: 129: 21.83
+	Hs
		476160 UBC_HUMAN (1-685): 0: 846: 100.00		RN166_HUMAN (11-179): 4.64e-29: 116: 23.26
+	Hs
		397944 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00
+	Rn
		78208 UBC_RAT (1-108): 1.27e-29: 127: 90.74		B5DFH7_RAT (1-501): 1.66e-151: 443: 86.43
+	Hs
		924227 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08
+	Rn
		88507 UBC_RAT (1-108): 1.27e-29: 127: 90.74		D3Z9G0_RAT (9-501): 8.62e-114: 349: 31.57
+	Mm
		476671 UBB_MOUSE (457-685): 2.3e-86: 275: 99.56		RO52_MOUSE (17-369): 1.05e-57: 200: 14.53
+	Mm
		476826 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		TRAF4_MOUSE (17-498): 1.4e-92: 291: 28.92
+	Mm
		924236 RS27A_MOUSE (609-684): 9.1e-41: 147: 100.00		RO52_MOUSE (17-369): 1.05e-57: 200: 14.53
+	Mm
		476831 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RO52_MOUSE (17-369): 1.05e-57: 200: 14.53
+	Hs
		923989 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TRI25_HUMAN (27-347): 1.26e-39: 153: 12.95