HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBP4 (Q13107)
Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog)
Gene: USP4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.968

Property	Details
Experiments	29576527, 33141564, 34642328, 38803224, 16196087, 20595234, 25404403, 30150323, 22195557
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DUSP~ubiquitin, UCH~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 963
+	Hs
		476624 UBC_HUMAN (1-685): 0: 846: 100.00		UBP15_HUMAN (1-924): 0: 749: 58.17
+	Hs
		475502 UBC_HUMAN (1-685): 0: 846: 100.00		UBP11_HUMAN (6-937): 0: 717: 44.60
+	Hs
		301354 UBC_HUMAN (1-685): 0: 846: 100.00		UBP19_HUMAN (183-937): 6.87e-148: 474: 30.87
+	Hs
		476097 UBC_HUMAN (1-685): 0: 846: 100.00		UBP33_HUMAN (203-962): 7.87e-114: 374: 18.72
+	Hs
		476599 UBC_HUMAN (1-685): 0: 846: 100.00		UBP20_HUMAN (203-962): 3.45e-110: 363: 17.72
+	Hs
		476644 UBC_HUMAN (1-685): 0: 846: 100.00		UBP16_HUMAN (245-922): 2.34e-97: 326: 17.57
+	Hs
		475957 UBC_HUMAN (1-685): 0: 846: 100.00		UBP45_HUMAN (179-922): 3.26e-95: 321: 17.31
+	Hs
		475990 UBC_HUMAN (1-685): 0: 846: 100.00		UBP37_HUMAN (164-938): 7.6e-90: 309: 14.43
+	Hs
		475440 UBC_HUMAN (1-685): 0: 846: 100.00		UBP8_HUMAN (546-932): 1.79e-62: 232: 22.06
+	Hs
		271022 UBC_HUMAN (1-685): 0: 846: 100.00		UBP2_HUMAN (604-928): 8.22e-65: 231: 23.55
+	Hs
		476545 UBC_HUMAN (1-685): 0: 846: 100.00		UBP21_HUMAN (651-928): 3.71e-63: 226: 25.00
+	Hs
		476579 UBC_HUMAN (1-685): 0: 846: 100.00		UBP22_HUMAN (764-928): 2.7e-60: 216: 28.33
+	Hs
		475932 UBC_HUMAN (1-685): 0: 846: 100.00		U17L2_HUMAN (737-935): 1.07e-56: 206: 26.50
+	Hs
		475403 UBC_HUMAN (1-685): 0: 846: 100.00		UBP6_HUMAN (850-954): 5.21e-22: 105: 28.30
+	Hs
		476067 UBC_HUMAN (1-685): 0: 846: 100.00		UBP32_HUMAN (850-954): 1.99e-21: 103: 28.30
+	Hs
		476658 UBC_HUMAN (1-685): 0: 846: 100.00		UBP3_HUMAN (303-482): 1e-15: 83.2: 29.74
+	Hs
		475954 UBC_HUMAN (1-685): 0: 846: 100.00		UBP31_HUMAN (484-741): 2.35e-14: 80: 8.45
+	Sc
		477294 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP5_YEAST (753-922): 1.13e-18: 93.6: 33.69
+	Sc
		477284 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP12_YEAST (479-755): 4.19e-15: 82.3: 7.67
+	Mm
		101489 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP32_MOUSE (850-954): 2.89e-21: 102: 28.30