HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

Property	Details
Experiments	27001857, 16964240, 21145461, 19295130
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cullin~ubiquitin, Cullin_Nedd8~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 759
+	Hs
		475730 UBC_HUMAN (1-685): 0: 846: 100.00		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		475728 UBC_HUMAN (1-685): 0: 846: 100.00		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		475726 UBC_HUMAN (1-685): 0: 846: 100.00		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		475727 UBC_HUMAN (1-685): 0: 846: 100.00		CUL2_HUMAN (51-759): 0: 710: 27.00
+	Hs
		476148 UBC_HUMAN (1-685): 0: 846: 100.00		CUL5_HUMAN (59-759): 0: 589: 24.94
+	Sp
		142914 UBI4P_SCHPO (305-685): 1.76e-151: 445: 95.80		CUL1_SCHPO (62-759): 0: 680: 29.27
+	Hs
		923984 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Rn
		71349 UBC_RAT (1-108): 1.27e-29: 127: 90.74		B2RYJ3_RAT (1-759): 0: 975: 94.99
+	Hs
		923985 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	At
		1352191 RUB1_ARATH (457-609): 8.21e-49: 169: 78.43		CUL3A_ARATH (36-759): 0: 853: 38.26
+	At
		1091919 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		CUL1_ARATH (57-759): 0: 744: 34.20
+	At
		1321116 RUB1_ARATH (457-609): 8.21e-49: 169: 78.43		CUL3B_ARATH (36-759): 0: 841: 37.99
+	Hs
		923983 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Rn
		78188 UBC_RAT (1-108): 1.27e-29: 127: 90.74		CUL3_RAT (32-759): 0: 814: 38.36
+	Mm
		477034 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		CUL3_MOUSE (32-759): 0: 813: 38.36
+	At
		1277343 RUB1_ARATH (457-609): 8.21e-49: 169: 78.43		CUL1_ARATH (57-759): 0: 744: 34.20
+	At
		1247030 RUB2_ARATH (457-608): 1.43e-47: 166: 78.29		CUL1_ARATH (57-759): 0: 744: 34.20
+	Rn
		70071 UBC_RAT (1-108): 1.27e-29: 127: 90.74		B1WBY1_RAT (59-759): 0: 745: 30.55
+	Mm
		477001 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		CUL2_MOUSE (51-759): 0: 717: 27.26
+	Mm
		477002 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		CUL5_MOUSE (59-759): 0: 589: 25.20