HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: CUL4B (Q13620)
Cullin-4B (CUL-4B)
Gene: CUL4B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.840

Property	Details
Experiments	21145461, 34642328, 23314748
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Cullin~ubiquitin, Cullin_Nedd8~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0031625 - ubiquitin protein ligase binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 913
+	Hs
		475729 UBC_HUMAN (1-685): 0: 846: 100.00		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Hs
		475728 UBC_HUMAN (1-685): 0: 846: 100.00		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		475726 UBC_HUMAN (1-685): 0: 846: 100.00		CUL1_HUMAN (213-913): 0: 778: 30.16
+	Hs
		475727 UBC_HUMAN (1-685): 0: 846: 100.00		CUL2_HUMAN (205-913): 0: 746: 27.53
+	Hs
		476148 UBC_HUMAN (1-685): 0: 846: 100.00		CUL5_HUMAN (213-913): 0: 610: 26.23
+	Hs
		923985 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		CUL4B_HUMAN (1-913): 0: 1184: 100.00
+	Sp
		142914 UBI4P_SCHPO (305-685): 1.76e-151: 445: 95.80		CUL1_SCHPO (201-913): 0: 718: 28.79
+	Hs
		923984 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Rn
		71349 UBC_RAT (1-108): 1.27e-29: 127: 90.74		B2RYJ3_RAT (161-913): 0: 965: 82.10
+	At
		1091919 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		CUL1_ARATH (211-913): 0: 787: 33.65
+	At
		1352191 RUB1_ARATH (457-609): 8.21e-49: 169: 78.43		CUL3A_ARATH (190-913): 0: 890: 39.35
+	At
		1321116 RUB1_ARATH (457-609): 8.21e-49: 169: 78.43		CUL3B_ARATH (190-913): 0: 878: 38.54
+	Hs
		923983 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Rn
		78188 UBC_RAT (1-108): 1.27e-29: 127: 90.74		CUL3_RAT (186-913): 0: 853: 37.19
+	Mm
		477034 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		CUL3_MOUSE (186-913): 0: 852: 37.19
+	At
		1277343 RUB1_ARATH (457-609): 8.21e-49: 169: 78.43		CUL1_ARATH (211-913): 0: 787: 33.65
+	At
		1247030 RUB2_ARATH (457-608): 1.43e-47: 166: 78.29		CUL1_ARATH (211-913): 0: 787: 33.65
+	Rn
		70071 UBC_RAT (1-108): 1.27e-29: 127: 90.74		B1WBY1_RAT (213-913): 0: 778: 30.16
+	Mm
		477001 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		CUL2_MOUSE (205-913): 0: 752: 27.66
+	Mm
		477002 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		CUL5_MOUSE (213-913): 0: 611: 26.23