HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: HERC3 (Q15034)
Probable E3 ubiquitin-protein ligase HERC3 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 3) (HECT-type E3 ubiquitin transferase HERC3)
Gene: HERC3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11163799
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 1050
+	Hs
		475871 UBC_HUMAN (1-685): 0: 846: 100.00		HERC4_HUMAN (1-1049): 0: 1067: 55.72
+	Hs
		475652 UBC_HUMAN (1-685): 0: 846: 100.00		UBE3A_HUMAN (460-1049): 1.23e-180: 550: 28.43
+	Hs
		476205 UBC_HUMAN (1-685): 0: 846: 100.00		ITCH_HUMAN (604-1048): 8.2e-178: 544: 26.60
+	Hs
		125113 UBC_HUMAN (1-685): 0: 846: 100.00		WWP2_HUMAN (573-1048): 1.25e-175: 537: 23.06
+	Hs
		476350 UBC_HUMAN (1-685): 0: 846: 100.00		WWP1_HUMAN (605-1048): 6.26e-173: 532: 24.09
+	Hs
		476414 UBC_HUMAN (1-685): 0: 846: 100.00		SMUF1_HUMAN (596-1047): 4.57e-174: 529: 25.91
+	Hs
		475470 UBC_HUMAN (1-685): 0: 846: 100.00		NEDD4_HUMAN (604-1048): 8.67e-167: 527: 24.22
+	Hs
		476229 UBC_HUMAN (1-685): 0: 846: 100.00		NED4L_HUMAN (606-1048): 2.42e-169: 524: 25.21
+	Hs
		476403 UBC_HUMAN (1-685): 0: 846: 100.00		SMUF2_HUMAN (557-1047): 1.53e-170: 519: 23.66
+	Mm
		476846 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		HERC4_MOUSE (1-1049): 0: 1094: 55.35
+	Dm
		89879 UBIQP_DROME (1-610): 0: 752: 99.84		D5SHR3_DROME (692-1049): 3.17e-152: 460: 29.92
+	Dm
		1376481 Q9W418_DROME (229-685): 0: 557: 99.78		Q9W325_DROME (692-1049): 5.54e-152: 460: 29.92
+	Hs
		475811 UBC_HUMAN (1-685): 0: 846: 100.00		HERC1_HUMAN (22-163): 6.56e-11: 69.3: 30.82
+	Sc
		477293 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		RSP5_YEAST (683-1048): 2.13e-157: 487: 29.18
+	Hs
		125347 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		WWP2_HUMAN (573-1048): 1.25e-175: 537: 23.06
+	Hs
		924156 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		WWP1_HUMAN (605-1048): 6.26e-173: 532: 24.09
+	Mm
		477022 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBE3B_MOUSE (473-1050): 1.41e-165: 517: 18.57
+	Mm
		476802 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		HERC2_MOUSE (129-341): 2.06e-17: 90.5: 26.12
+	Rn
		89006 UBC_RAT (1-108): 1.27e-29: 127: 90.74		D4ACN3_RAT (129-341): 2.19e-17: 90.5: 26.12
+	Mm
		93336 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		E9PZP8_MOUSE (22-163): 2.1e-10: 67.4: 29.45