HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBE3C (Q15386)
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)
Gene: UBE3C

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.80	0.841

Property	Details
Experiments	14517261, 25752577, 25723849, 26389696, 30503554, 16601690
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 1083
+	Hs
		475963 UBC_HUMAN (1-685): 0: 846: 100.00		HECW1_HUMAN (248-1082): 0: 699: 20.74
+	Hs
		475470 UBC_HUMAN (1-685): 0: 846: 100.00		NEDD4_HUMAN (291-1081): 4.42e-178: 558: 20.10
+	Hs
		475652 UBC_HUMAN (1-685): 0: 846: 100.00		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		476205 UBC_HUMAN (1-685): 0: 846: 100.00		ITCH_HUMAN (594-1081): 5.52e-180: 550: 25.46
+	Hs
		125113 UBC_HUMAN (1-685): 0: 846: 100.00		WWP2_HUMAN (592-1081): 3.93e-177: 542: 25.10
+	Hs
		476403 UBC_HUMAN (1-685): 0: 846: 100.00		SMUF2_HUMAN (557-1080): 7.6e-179: 542: 22.77
+	Hs
		476414 UBC_HUMAN (1-685): 0: 846: 100.00		SMUF1_HUMAN (562-1080): 3.14e-177: 539: 22.78
+	Hs
		476229 UBC_HUMAN (1-685): 0: 846: 100.00		NED4L_HUMAN (572-1081): 2.17e-174: 538: 25.33
+	Hs
		476350 UBC_HUMAN (1-685): 0: 846: 100.00		WWP1_HUMAN (599-1081): 1.77e-174: 537: 25.66
+	Dm
		89879 UBIQP_DROME (1-610): 0: 752: 99.84		D5SHR3_DROME (666-1082): 4.99e-148: 451: 30.19
+	Hs
		475984 UBC_HUMAN (1-685): 0: 846: 100.00		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Sc
		477293 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		RSP5_YEAST (489-1081): 1.73e-170: 523: 21.30
+	At
		1091762 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UPL2_ARATH (329-1083): 0: 606: 23.76
+	At
		1091758 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UPL1_ARATH (329-1083): 4.66e-180: 586: 23.57
+	Hs
		125347 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		WWP2_HUMAN (592-1081): 3.93e-177: 542: 25.10
+	Hs
		924156 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		WWP1_HUMAN (599-1081): 1.77e-174: 537: 25.66
+	Sp
		143368 UBI4P_SCHPO (305-685): 1.76e-151: 445: 95.80		PTR1_SCHPO (683-1080): 4.07e-54: 209: 33.25
+	Sc
		477380 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		HUL5_YEAST (662-1083): 8.08e-75: 268: 39.07
+	Sc
		477424 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		TOM1_YEAST (683-1083): 1.4e-46: 185: 32.12
+	Mm
		924239 RS27A_MOUSE (609-684): 9.1e-41: 147: 100.00		HUWE1_MOUSE (683-1083): 1.45e-47: 188: 32.60