HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: HERC1 (Q15751)
Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619)
Gene: HERC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	28190767, 38803224
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 4861
+	Hs
		476403 UBC_HUMAN (1-685): 0: 846: 100.00		SMUF2_HUMAN (4334-4843): 2.33e-164: 530: 23.60
+	Hs
		476414 UBC_HUMAN (1-685): 0: 846: 100.00		SMUF1_HUMAN (4320-4843): 8.67e-163: 526: 22.58
+	Hs
		475470 UBC_HUMAN (1-685): 0: 846: 100.00		NEDD4_HUMAN (4360-4841): 3.39e-153: 517: 20.97
+	Hs
		476205 UBC_HUMAN (1-685): 0: 846: 100.00		ITCH_HUMAN (4369-4843): 2.48e-157: 516: 23.03
+	Hs
		476229 UBC_HUMAN (1-685): 0: 846: 100.00		NED4L_HUMAN (4355-4841): 1.54e-156: 516: 19.68
+	Hs
		476350 UBC_HUMAN (1-685): 0: 846: 100.00		WWP1_HUMAN (4368-4843): 2.69e-157: 516: 21.53
+	Hs
		125113 UBC_HUMAN (1-685): 0: 846: 100.00		WWP2_HUMAN (4369-4843): 4.38e-156: 511: 21.36
+	Hs
		475984 UBC_HUMAN (1-685): 0: 846: 100.00		HUWE1_HUMAN (4372-4842): 8.91e-133: 474: 21.86
+	Hs
		475652 UBC_HUMAN (1-685): 0: 846: 100.00		UBE3A_HUMAN (4457-4842): 3.46e-126: 424: 25.96
+	Dm
		89879 UBIQP_DROME (1-610): 0: 752: 99.84		D5SHR3_DROME (4410-4843): 6.63e-144: 458: 23.53
+	Dm
		1376481 Q9W418_DROME (229-685): 0: 557: 99.78		Q9W325_DROME (4428-4843): 9.87e-144: 458: 24.53
+	Sp
		143368 UBI4P_SCHPO (305-685): 1.76e-151: 445: 95.80		PTR1_SCHPO (4388-4841): 7.88e-138: 490: 23.38
+	Hs
		475871 UBC_HUMAN (1-685): 0: 846: 100.00		HERC4_HUMAN (4513-4836): 5.31e-12: 75.1: 24.77
+	Hs
		475785 UBC_HUMAN (1-685): 0: 846: 100.00		HERC3_HUMAN (602-747): 3.17e-10: 68.9: 30.82
+	Hs
		319697 UBC_HUMAN (1-685): 0: 846: 100.00		HERC2_HUMAN (593-845): 9.55e-10: 67.8: 15.81
+	Sc
		477293 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		RSP5_YEAST (4360-4843): 1.18e-149: 490: 20.20
+	At
		1091758 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UPL1_ARATH (4408-4841): 7.14e-136: 484: 23.65
+	At
		1091762 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UPL2_ARATH (4408-4841): 6.62e-135: 481: 23.65
+	Sc
		477424 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		TOM1_YEAST (4513-4835): 7.49e-36: 154: 30.30
+	At
		1092374 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		Q9SRZ7_ARATH (544-741): 6.1e-12: 74.7: 25.98