HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UB2R2 (Q712K3)
Ubiquitin-conjugating enzyme E2 R2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme R2) (Ubiquitin carrier protein R2) (Ubiquitin-conjugating enzyme E2-CDC34B) (Ubiquitin-protein ligase R2)
Gene: UBE2R2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.914

Property	Details
Experiments	27182664, 34642328, 27044868, 34942047, 21900206
Identification Methods	proximity labelling technology, pull down, enzymatic study, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	UQ_con~ubiquitin
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 238
+	Hs
		475483 UBC_HUMAN (1-685): 0: 846: 100.00		UB2R1_HUMAN (1-238): 4.37e-90: 266: 79.41
+	Hs
		476604 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D4_HUMAN (8-167): 7.92e-72: 217: 31.68
+	Hs
		475501 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D1_HUMAN (8-167): 2.78e-71: 216: 31.68
+	Hs
		475586 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D2_HUMAN (8-167): 2.85e-71: 216: 29.19
+	Hs
		475550 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D3_HUMAN (8-167): 3.59e-70: 213: 29.81
+	Hs
		475573 UBC_HUMAN (1-685): 0: 846: 100.00		UB2G1_HUMAN (13-174): 4.73e-69: 211: 51.85
+	Hs
		475543 UBC_HUMAN (1-685): 0: 846: 100.00		UB2G2_HUMAN (8-160): 1.03e-65: 202: 49.67
+	Xl
		919927 Q7SY79_XENLA (77-685): 0: 744: 99.84		UB2D2_XENLA (8-167): 2.85e-71: 216: 29.19
+	Hs
		475485 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2A_HUMAN (7-179): 1.37e-28: 107: 37.57
+	Hs
		475597 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2B_HUMAN (7-150): 1.87e-28: 107: 40.97
+	Dm
		639414 Q9W418_DROME (229-685): 0: 557: 99.78		UBCD1_DROME (8-167): 1.18e-70: 214: 30.44
+	Sc
		477098 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC3_YEAST (5-235): 3.47e-69: 216: 35.04
+	Sc
		477415 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC7_YEAST (8-161): 4.1e-68: 208: 45.46
+	Sc
		477103 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC4_YEAST (8-166): 1.66e-67: 206: 31.88
+	Sp
		116509 UBI4P_SCHPO (305-685): 1.76e-151: 445: 95.80		UBC11_SCHPO (8-150): 5e-26: 101: 40.56
+	At
		715116 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC8_ARATH (8-167): 2.7e-70: 213: 32.30
+	At
		715132 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC9_ARATH (8-167): 2.27e-69: 211: 31.68
+	At
		715147 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC10_ARATH (8-167): 1.42e-69: 211: 31.68
+	Sc
		410203 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC2_YEAST (7-149): 7.94e-25: 98.2: 36.36
+	At
		639385 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC1_ARATH (7-172): 9.13e-27: 102: 36.15