HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: TRI59 (Q8IWR1)
Tripartite motif-containing protein 59 (EC 2.3.2.27) (RING finger protein 104) (Tumor suppressor TSBF-1)
Gene: TRIM59

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30585270
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_UBOX
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0016567 - protein ubiquitination
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 403
+	Hs
		475328 UBC_HUMAN (1-685): 0: 846: 100.00		RO52_HUMAN (1-352): 8.74e-78: 249: 16.15
+	Hs
		476418 UBC_HUMAN (1-685): 0: 846: 100.00		TRI39_HUMAN (1-354): 1.52e-69: 229: 16.75
+	Hs
		476330 UBC_HUMAN (1-685): 0: 846: 100.00		TRIM5_HUMAN (1-329): 1.71e-68: 226: 21.52
+	Hs
		475297 UBC_HUMAN (1-685): 0: 846: 100.00		TRI27_HUMAN (2-353): 5.58e-67: 222: 15.63
+	Hs
		475680 UBC_HUMAN (1-685): 0: 846: 100.00		TRI26_HUMAN (1-352): 6.95e-66: 220: 15.00
+	Hs
		476635 UBC_HUMAN (1-685): 0: 846: 100.00		TRI17_HUMAN (2-335): 2.61e-60: 204: 16.52
+	Xl
		1186351 Q7SY79_XENLA (77-685): 0: 744: 99.84		NF7B_XENLA (3-354): 1.85e-67: 226: 17.32
+	Hs
		175634 UBC_HUMAN (1-685): 0: 846: 100.00		TRI18_HUMAN (1-88): 2.06e-13: 73.9: 37.50
+	Dr
		91588 F1QHN6_DANRE (229-685): 0: 555: 99.78		E7F1U3_DANRE (5-322): 6.71e-55: 195: 20.77
+	Mm
		476671 UBB_MOUSE (457-685): 2.3e-86: 275: 99.56		RO52_MOUSE (1-354): 1.51e-70: 230: 17.04
+	Mm
		924236 RS27A_MOUSE (609-684): 9.1e-41: 147: 100.00		RO52_MOUSE (1-354): 1.51e-70: 230: 17.04
+	Mm
		476831 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RO52_MOUSE (1-354): 1.51e-70: 230: 17.04
+	Hs
		475134 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		TRI11_HUMAN (3-354): 8.45e-72: 234: 19.55
+	Rn
		88684 UBC_RAT (1-108): 1.27e-29: 127: 90.74		TRIM2_RAT (5-336): 5.49e-60: 209: 18.29
+	Hs
		475177 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		TRIM5_HUMAN (1-329): 1.71e-68: 226: 21.52
+	Hs
		924151 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TRI31_HUMAN (1-270): 7.42e-13: 71.6: 25.09