HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: RN169 (Q8NCN4)
E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169)
Gene: RNF169

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.940

Property	Details
Experiments	22733822, 31699778, 38803224, 28406400, 30773093, 22742833
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4_3
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 708
+	Hs
		475328 UBC_HUMAN (1-685): 0: 846: 100.00		RO52_HUMAN (64-382): 1.63e-106: 334: 19.27
+	Hs
		476418 UBC_HUMAN (1-685): 0: 846: 100.00		TRI39_HUMAN (59-383): 1.17e-76: 257: 14.02
+	Hs
		475297 UBC_HUMAN (1-685): 0: 846: 100.00		TRI27_HUMAN (62-395): 2.25e-76: 256: 14.29
+	Hs
		476330 UBC_HUMAN (1-685): 0: 846: 100.00		TRIM5_HUMAN (59-367): 5.51e-74: 249: 14.42
+	Hs
		476635 UBC_HUMAN (1-685): 0: 846: 100.00		TRI17_HUMAN (59-381): 2.57e-67: 230: 13.66
+	Hs
		476036 UBC_HUMAN (1-685): 0: 846: 100.00		RN168_HUMAN (61-459): 1.85e-65: 228: 23.54
+	Hs
		475680 UBC_HUMAN (1-685): 0: 846: 100.00		TRI26_HUMAN (54-383): 8.51e-63: 220: 12.95
+	Xl
		1186351 Q7SY79_XENLA (77-685): 0: 744: 99.84		NF7B_XENLA (21-383): 1.07e-64: 227: 11.20
+	Mm
		476671 UBB_MOUSE (457-685): 2.3e-86: 275: 99.56		RO52_MOUSE (64-383): 1.66e-100: 318: 17.68
+	Mm
		924236 RS27A_MOUSE (609-684): 9.1e-41: 147: 100.00		RO52_MOUSE (64-383): 1.66e-100: 318: 17.68
+	Mm
		476872 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN168_MOUSE (61-455): 6.16e-105: 333: 17.65
+	Mm
		476831 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RO52_MOUSE (64-383): 1.66e-100: 318: 17.68
+	Hs
		475134 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		TRI11_HUMAN (62-383): 5.59e-83: 272: 17.37
+	Hs
		475177 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		TRIM5_HUMAN (59-367): 5.51e-74: 249: 14.42
+	Rn
		88684 UBC_RAT (1-108): 1.27e-29: 127: 90.74		TRIM2_RAT (66-461): 2.15e-61: 220: 12.18
+	Hs
		475096 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RN168_HUMAN (61-459): 1.85e-65: 228: 23.54
+	Hs
		924151 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TRI31_HUMAN (64-308): 8.03e-23: 103: 13.66