HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBS3B (Q8TF42)
Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)
Gene: UBASH3B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.937

Property	Details
Experiments	16429130, 28190767, 31494268, 15159412, 17599067, 19380743
Identification Methods	pull down, unspecified method, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH3_9~ubiquitin, UBA~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 649
+	Hs
		475540 UBC_HUMAN (1-685): 0: 846: 100.00		UBS3A_HUMAN (12-643): 0: 947: 43.37
+	Hs
		924089 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		UBS3B_HUMAN (1-649): 0: 1066: 100.00
+	Mm
		476878 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBS3B_MOUSE (12-649): 0: 1037: 97.65
+	Hs
		475592 UBC_HUMAN (1-685): 0: 846: 100.00		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		476167 UBC_HUMAN (1-685): 0: 846: 100.00		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00
+	Hs
		475650 UBC_HUMAN (1-685): 0: 846: 100.00		UBXN1_HUMAN (35-97): 3.55e-22: 99.1: 47.69
+	Hs
		475981 UBC_HUMAN (1-685): 0: 846: 100.00		SH3R1_HUMAN (216-315): 3.02e-18: 91.4: 28.00
+	Hs
		476095 UBC_HUMAN (1-685): 0: 846: 100.00		SH3R3_HUMAN (195-315): 4.01e-15: 81.4: 22.13
+	Xl
		1155575 Q7SY79_XENLA (77-685): 0: 744: 99.84		SH3R1_XENLA (219-315): 2.75e-15: 81.8: 25.77
+	Hs
		923946 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Rn
		924996 UBC_RAT (1-108): 1.27e-29: 127: 90.74		GRB2_RAT (156-319): 1.37e-45: 163: 21.56
+	Hs
		474986 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Mm
		476957 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBXN1_MOUSE (35-97): 7.24e-21: 95.2: 49.23
+	Hs
		596208 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		NEBU_HUMAN (256-315): 6.87e-11: 67.9: 33.33
+	Hs
		397924 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		UBXN1_HUMAN (35-97): 3.55e-22: 99.1: 47.69