HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.988

Property	Details
Experiments	18212736, 21408173, 23178947, 28190767, 29133525, 19285159, 17702576, 21862579, 21617041, 26451915, 26365381, 25969509, 27035970, 27552911, 28319114, 29394115, 31155706, 23414517
Identification Methods	two hybrid, pull down, enzymatic study, affinity chromatography technology, protein array, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CC2-LZ~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 577
+	Hs
		476660 UBC_HUMAN (1-685): 0: 846: 100.00		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		475279 UBC_HUMAN (1-685): 0: 846: 100.00		LAMC1_HUMAN (59-543): 3.86e-30: 128: 13.64
+	Hs
		475816 UBC_HUMAN (1-685): 0: 846: 100.00		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Hs
		475773 UBC_HUMAN (1-685): 0: 846: 100.00		NUMA1_HUMAN (4-572): 1.29e-14: 79.5: 12.87
+	Hs
		475291 UBC_HUMAN (1-685): 0: 846: 100.00		MYH1_HUMAN (226-567): 1.98e-11: 69.5: 11.82
+	Hs
		475417 UBC_HUMAN (1-685): 0: 846: 100.00		MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08
+	Hs
		924113 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Rn
		655929 UBC_RAT (1-108): 1.27e-29: 127: 90.74		DCTN1_RAT (199-553): 6.35e-55: 202: 17.53
+	Rn
		1144239 UBC_RAT (1-108): 1.27e-29: 127: 90.74		OPTN_RAT (1-577): 7.48e-44: 166: 77.53
+	Mm
		291775 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		NEMO_MOUSE (204-576): 2.74e-40: 153: 25.33
+	Hs
		924144 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		CP250_HUMAN (15-545): 9.03e-15: 80.3: 11.07
+	Hs
		923995 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		NUMA1_HUMAN (4-572): 1.29e-14: 79.5: 12.87
+	Hs
		148651 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Mm
		476828 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		MYH10_MOUSE (233-561): 5.58e-13: 74.5: 11.18
+	Mm
		477062 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		ITSN1_MOUSE (1-363): 2.07e-11: 69.3: 12.09
+	Hs
		398052 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		MY18A_HUMAN (73-548): 2.87e-14: 78.5: 12.99
+	Mm
		476930 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		MYH9_MOUSE (266-576): 6.92e-10: 64.5: 13.51
+	Hs
		397814 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		MYH10_HUMAN (233-561): 3.51e-13: 74.9: 10.88
+	Hs
		398102 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		MYO5C_HUMAN (39-462): 1.18e-12: 73.1: 14.87
+	Hs
		397813 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08