HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: RNF31 (Q96EP0)
E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)
Gene: RNF31

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.989

Property	Details
Experiments	20005846, 28190767, 34599178, 35170849, 38803224, 17006537, 23986494, 25494483, 26789245, 22791023, 28319114, 28978479, 30017913, 30901564, 29694895, 35851409, 36631489, 36720498, 23727886, 24469399 and 2 others more... 24726327, 21455180
Identification Methods	pull down, affinity chromatography technology, enzymatic study, x-ray crystallography
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	E3_UbLigase_RBR~ubiquitin, IBR~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 1072
+	Hs
		475133 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RNF31_HUMAN (1-1072): 0: 1111: 100.00
+	Hs
		476630 UBC_HUMAN (1-685): 0: 846: 100.00		ARI1_HUMAN (600-1058): 1.52e-114: 367: 13.84
+	Mm
		476959 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RNF31_MOUSE (1-1072): 0: 1083: 85.54
+	Hs
		312458 UBC_HUMAN (1-685): 0: 846: 100.00		ARI2_HUMAN (654-1044): 9.03e-91: 301: 15.84
+	Hs
		476496 UBC_HUMAN (1-685): 0: 846: 100.00		AKIB1_HUMAN (431-1040): 1.61e-81: 290: 12.26
+	Hs
		475976 UBC_HUMAN (1-685): 0: 846: 100.00		R144B_HUMAN (679-926): 3.22e-60: 210: 20.23
+	Hs
		475494 UBC_HUMAN (1-685): 0: 846: 100.00		R144A_HUMAN (695-926): 5.41e-59: 206: 20.33
+	Hs
		475939 UBC_HUMAN (1-685): 0: 846: 100.00		RN19B_HUMAN (698-946): 5.65e-42: 167: 22.43
+	Dm
		477528 UBIQP_DROME (1-610): 0: 752: 99.84		LUBEL_DROME (180-625): 2.05e-69: 257: 17.33
+	Hs
		476517 UBC_HUMAN (1-685): 0: 846: 100.00		ZRAN1_HUMAN (226-379): 5.88e-20: 97.7: 19.44
+	Dm
		1214032 Q9W418_DROME (229-685): 0: 557: 99.78		LUBEL_DROME (180-625): 2.05e-69: 257: 17.33
+	Sc
		477225 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		HEL1_YEAST (621-1042): 5.5e-90: 301: 14.92
+	Dr
		48762 F1QHN6_DANRE (229-685): 0: 555: 99.78		ZRN1B_DANRE (159-353): 2.47e-13: 76.6: 15.42
+	Hs
		475094 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		CUL9_HUMAN (622-1043): 1.8e-86: 309: 16.09
+	Hs
		312457 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		ARI2_HUMAN (654-1044): 9.03e-91: 301: 15.84
+	Mm
		476729 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN216_MOUSE (609-992): 9.79e-62: 228: 13.97
+	Hs
		475069 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RN19B_HUMAN (698-946): 5.65e-42: 167: 22.43
+	Hs
		924207 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		ZRAN1_HUMAN (226-379): 5.88e-20: 97.7: 19.44
+	Mm
		476855 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		ZRAN1_MOUSE (159-354): 1.1e-12: 74.3: 14.63