HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.956

Property	Details
Experiments	28461335, 20064473, 25752577, 29964046, 22496338, 23644597, 19343052
Identification Methods	pull down, x-ray crystallography, enzymatic study
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 975
+	Hs
		476350 UBC_HUMAN (1-685): 0: 846: 100.00		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		476205 UBC_HUMAN (1-685): 0: 846: 100.00		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		475470 UBC_HUMAN (1-685): 0: 846: 100.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125113 UBC_HUMAN (1-685): 0: 846: 100.00		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		475984 UBC_HUMAN (1-685): 0: 846: 100.00		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Dm
		89879 UBIQP_DROME (1-610): 0: 752: 99.84		D5SHR3_DROME (554-972): 0: 535: 44.58
+	Dm
		1376481 Q9W418_DROME (229-685): 0: 557: 99.78		Q9W325_DROME (554-972): 4.64e-180: 531: 44.58
+	Hs
		476414 UBC_HUMAN (1-685): 0: 846: 100.00		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		476403 UBC_HUMAN (1-685): 0: 846: 100.00		SMUF2_HUMAN (21-324): 2e-29: 127: 22.56
+	Sp
		143368 UBI4P_SCHPO (305-685): 1.76e-151: 445: 95.80		PTR1_SCHPO (326-972): 8.39e-161: 526: 27.83
+	Hs
		924156 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		475963 UBC_HUMAN (1-685): 0: 846: 100.00		HECW1_HUMAN (144-528): 1.92e-09: 64.2: 13.73
+	Sc
		477424 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		TOM1_YEAST (549-973): 3.97e-159: 521: 39.91
+	Hs
		125347 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		WWP2_HUMAN (228-972): 0: 719: 37.80
+	At
		1091758 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UPL1_ARATH (556-972): 7.05e-160: 524: 39.63
+	At
		1091762 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UPL2_ARATH (556-972): 1.55e-158: 520: 39.16
+	Mm
		924239 RS27A_MOUSE (609-684): 9.1e-41: 147: 100.00		HUWE1_MOUSE (372-973): 2.88e-171: 557: 33.66
+	Mm
		476858 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		HUWE1_MOUSE (372-973): 2.88e-171: 557: 33.66
+	Ce
		477557 UBIQ1_CAEEL (1-229): 5.97e-87: 292: 98.25		Q9GUP2_CAEEL (582-971): 1.14e-86: 308: 42.51
+	Sc
		477293 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		RSP5_YEAST (22-487): 5.51e-24: 110: 17.06