HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBP28 (Q96RU2)
Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28)
Gene: USP28

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.977

Property	Details
Experiments	29576527, 25359778, 26268556, 29131570, 30926243, 30926242, 32963944, 34129829, 22626734
Identification Methods	pull down, enzymatic study, x-ray crystallography
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	UCH~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 1077
+	Hs
		476529 UBC_HUMAN (1-685): 0: 846: 100.00		UBP25_HUMAN (1-1068): 0: 977: 48.38
+	Hs
		475461 UBC_HUMAN (1-685): 0: 846: 100.00		UBP5_HUMAN (28-649): 4.98e-77: 273: 12.71
+	Hs
		475995 UBC_HUMAN (1-685): 0: 846: 100.00		UBP48_HUMAN (145-399): 5.66e-73: 264: 26.52
+	Hs
		476145 UBC_HUMAN (1-685): 0: 846: 100.00		UBP13_HUMAN (28-649): 3.31e-72: 259: 12.85
+	Hs
		476452 UBC_HUMAN (1-685): 0: 846: 100.00		UBP40_HUMAN (120-715): 1.07e-69: 256: 14.68
+	Hs
		475952 UBC_HUMAN (1-685): 0: 846: 100.00		UBP34_HUMAN (151-417): 5.88e-65: 243: 24.64
+	Hs
		476146 UBC_HUMAN (1-685): 0: 846: 100.00		USP9X_HUMAN (136-452): 1.14e-61: 233: 18.33
+	Hs
		259261 UBC_HUMAN (1-685): 0: 846: 100.00		UBP12_HUMAN (157-475): 5.94e-65: 226: 17.10
+	Hs
		475566 UBC_HUMAN (1-685): 0: 846: 100.00		UBP46_HUMAN (158-406): 1.63e-64: 224: 20.36
+	Hs
		476213 UBC_HUMAN (1-685): 0: 846: 100.00		UBP47_HUMAN (156-403): 7.25e-49: 191: 19.85
+	Hs
		131635 UBC_HUMAN (1-685): 0: 846: 100.00		USP9Y_HUMAN (156-417): 3.4e-40: 164: 20.00
+	Hs
		476067 UBC_HUMAN (1-685): 0: 846: 100.00		UBP32_HUMAN (62-327): 5.03e-33: 141: 17.11
+	Hs
		476147 UBC_HUMAN (1-685): 0: 846: 100.00		UBP7_HUMAN (547-839): 8.01e-23: 107: 20.13
+	Hs
		475932 UBC_HUMAN (1-685): 0: 846: 100.00		U17L2_HUMAN (446-745): 3.74e-21: 100: 13.49
+	Hs
		271022 UBC_HUMAN (1-685): 0: 846: 100.00		UBP2_HUMAN (434-653): 1.59e-15: 83.1: 17.86
+	Hs
		64200 UBC_HUMAN (1-685): 0: 846: 100.00		UBP27_HUMAN (562-658): 1.93e-11: 69.6: 22.68
+	Hs
		476579 UBC_HUMAN (1-685): 0: 846: 100.00		UBP22_HUMAN (428-654): 3.12e-11: 69.2: 18.42
+	Hs
		476400 UBC_HUMAN (1-685): 0: 846: 100.00		UBP42_HUMAN (481-651): 4.17e-10: 66.5: 19.77
+	Hs
		476493 UBC_HUMAN (1-685): 0: 846: 100.00		UBP36_HUMAN (473-649): 5.03e-09: 62.7: 17.98
+	At
		1210479 UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80		UBP15_ARATH (493-764): 3.68e-10: 66.5: 14.91