HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: MEP50 (Q9BQA1)
Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50)
Gene: WDR77

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	38803224, 16196087
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 342
+	Hs
		476334 UBC_HUMAN (1-685): 0: 846: 100.00		WDR33_HUMAN (58-331): 3.52e-67: 230: 17.86
+	Hs
		476151 UBC_HUMAN (1-685): 0: 846: 100.00		FBXW7_HUMAN (3-236): 5.23e-43: 159: 14.29
+	Hs
		475563 UBC_HUMAN (1-685): 0: 846: 100.00		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Hs
		196947 UBC_HUMAN (1-685): 0: 846: 100.00		PRP4_HUMAN (253-341): 3.86e-10: 62.8: 13.40
+	Sc
		477239 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		TAF5_YEAST (15-267): 2.96e-38: 146: 14.77
+	Sc
		477393 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		COPA_YEAST (131-323): 1.27e-23: 104: 16.81
+	Sc
		477328 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		COPB2_YEAST (15-314): 1.99e-22: 100: 14.47
+	Hs
		924132 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		MEP50_HUMAN (1-342): 6.74e-81: 251: 100.00
+	Rn
		925834 UBC_RAT (1-108): 1.27e-29: 127: 90.74		LIS1_RAT (62-339): 6.17e-75: 238: 16.72
+	Hs
		397828 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		LIS1_HUMAN (62-339): 9.49e-75: 238: 16.72
+	At
		1091825 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		Q8RXQ4_ARATH (155-323): 2.14e-15: 78.4: 17.06
+	Hs
		398088 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		WDR33_HUMAN (58-331): 3.52e-67: 230: 17.86
+	Hs
		725413 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		COPB2_HUMAN (54-331): 3.17e-47: 172: 18.38
+	Rn
		192311 UBC_RAT (1-108): 1.27e-29: 127: 90.74		COPB2_RAT (27-331): 6.35e-47: 171: 17.42
+	Hs
		397815 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		COPB2_HUMAN (54-331): 3.17e-47: 172: 18.38
+	Hs
		903105 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Hs
		475104 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		WDR31_HUMAN (80-286): 3.32e-20: 92.2: 21.50