HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: RN181 (Q9P0P0)
E3 ubiquitin-protein ligase RNF181 (EC 2.3.2.27) (RING finger protein 181)
Gene: RNF181

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	26711259
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_2
Common GO terms	GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 153
+	Hs
		476628 UBC_HUMAN (1-685): 0: 846: 100.00		RN115_HUMAN (12-148): 1.96e-29: 110: 30.28
+	Hs
		476458 UBC_HUMAN (1-685): 0: 846: 100.00		RNF12_HUMAN (13-120): 5.71e-28: 109: 26.85
+	Hs
		476073 UBC_HUMAN (1-685): 0: 846: 100.00		PJA1_HUMAN (52-122): 4.69e-27: 107: 38.67
+	Hs
		476007 UBC_HUMAN (1-685): 0: 846: 100.00		GOLI_HUMAN (23-149): 5.46e-27: 106: 22.38
+	Hs
		476301 UBC_HUMAN (1-685): 0: 846: 100.00		RN126_HUMAN (33-130): 2.66e-26: 102: 33.00
+	At
		1210477 UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80		Q9FM98_ARATH (14-151): 6.79e-26: 102: 33.09
+	At
		1091813 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		RNG1L_ARATH (36-153): 7.48e-30: 112: 33.06
+	At
		1092053 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		Q9FM98_ARATH (14-151): 6.79e-26: 102: 33.09
+	At
		1092416 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		ATL18_ARATH (71-117): 7.9e-11: 58.2: 51.02
+	At
		477669 UBQ11_ARATH (533-685): 2.54e-59: 201: 95.43		Q9FM98_ARATH (14-151): 6.79e-26: 102: 33.09
+	Hs
		924199 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		RN181_HUMAN (1-153): 1.15e-42: 140: 100.00
+	Mm
		476987 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN181_MOUSE (1-153): 7.67e-42: 138: 77.71
+	Hs
		924057 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		GOLI_HUMAN (23-149): 5.46e-27: 106: 22.38
+	Hs
		475216 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RN181_HUMAN (1-153): 1.15e-42: 140: 100.00
+	Mm
		476994 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN115_MOUSE (12-148): 9.25e-29: 108: 29.58
+	Mm
		477051 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RNF12_MOUSE (12-125): 9.24e-27: 106: 26.32
+	Mm
		476947 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN126_MOUSE (33-130): 3.7e-27: 104: 34.00
+	Hs
		398150 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		RN115_HUMAN (12-148): 1.96e-29: 110: 30.28
+	Hs
		475090 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		GOLI_HUMAN (23-149): 5.46e-27: 106: 22.38
+	Hs
		475173 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RN126_HUMAN (33-130): 2.66e-26: 102: 33.00