HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: IBTK (Q9P2D0)
Inhibitor of Bruton tyrosine kinase (IBtk)
Gene: IBTK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25882842
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 1353
+	Hs
		398123 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		IBTK_HUMAN (1-1353): 0: 1106: 100.00
+	Mm
		476851 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		IBTK_MOUSE (1-1353): 0: 1037: 85.75
+	Hs
		475811 UBC_HUMAN (1-685): 0: 846: 100.00		HERC1_HUMAN (130-455): 4.25e-63: 240: 20.59
+	Hs
		475871 UBC_HUMAN (1-685): 0: 846: 100.00		HERC4_HUMAN (27-328): 1.85e-50: 197: 22.90
+	Hs
		475785 UBC_HUMAN (1-685): 0: 846: 100.00		HERC3_HUMAN (11-302): 1.95e-39: 162: 17.35
+	Hs
		475320 UBC_HUMAN (1-685): 0: 846: 100.00		RCC1_HUMAN (47-411): 2.58e-39: 154: 18.81
+	Dm
		477535 UBIQP_DROME (1-610): 0: 752: 99.84		RDX_DROME (707-931): 3.24e-64: 237: 24.44
+	Hs
		319697 UBC_HUMAN (1-685): 0: 846: 100.00		HERC2_HUMAN (16-249): 6.62e-19: 95.9: 16.60
+	Hs
		476456 UBC_HUMAN (1-685): 0: 846: 100.00		KLH11_HUMAN (761-922): 2.45e-12: 73.6: 30.41
+	Hs
		475987 UBC_HUMAN (1-685): 0: 846: 100.00		NEK8_HUMAN (249-427): 7.01e-12: 72.1: 20.42
+	Dm
		1365593 Q9W418_DROME (229-685): 0: 557: 99.78		RDX_DROME (707-931): 3.24e-64: 237: 24.44
+	At
		1092374 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		Q9SRZ7_ARATH (155-700): 4.8e-77: 278: 16.83
+	Mm
		93336 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		E9PZP8_MOUSE (95-455): 1.29e-63: 242: 20.00
+	Mm
		476846 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		HERC4_MOUSE (253-577): 3.21e-50: 196: 15.09
+	Hs
		398000 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		HERC4_HUMAN (27-328): 1.85e-50: 197: 22.90
+	Hs
		398132 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		HERC5_HUMAN (127-355): 7.82e-42: 169: 24.48
+	Hs
		397975 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		HERC3_HUMAN (11-302): 1.95e-39: 162: 17.35
+	Hs
		1076136 OASL_HUMAN (1-153): 6.51e-17: 86.3: 29.11		HERC5_HUMAN (127-355): 7.82e-42: 169: 24.48
+	Mm
		476802 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		HERC2_MOUSE (16-249): 3.99e-19: 96.6: 15.90
+	Rn
		89006 UBC_RAT (1-108): 1.27e-29: 127: 90.74		D4ACN3_RAT (16-249): 7.46e-19: 95.9: 15.90