HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBP21 (Q9UK80)
Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21)
Gene: USP21

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.976

Property	Details
Experiments	21399617, 25527291, 27436899, 28943312, 28536428, 27501351, 20622874, 22195557, 22298430, 22626734, 23287719
Identification Methods	enzymatic study, pull down, unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UCH~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 565
+	Hs
		271022 UBC_HUMAN (1-685): 0: 846: 100.00		UBP2_HUMAN (86-564): 1.45e-129: 393: 37.99
+	Hs
		475440 UBC_HUMAN (1-685): 0: 846: 100.00		UBP8_HUMAN (16-561): 5.91e-122: 387: 24.21
+	Hs
		476400 UBC_HUMAN (1-685): 0: 846: 100.00		UBP42_HUMAN (89-558): 1.55e-103: 341: 23.47
+	Hs
		476579 UBC_HUMAN (1-685): 0: 846: 100.00		UBP22_HUMAN (170-558): 1.39e-110: 341: 24.94
+	Hs
		64200 UBC_HUMAN (1-685): 0: 846: 100.00		UBP27_HUMAN (142-558): 1.71e-110: 338: 23.01
+	Hs
		475566 UBC_HUMAN (1-685): 0: 846: 100.00		UBP46_HUMAN (197-558): 1.8e-110: 336: 23.81
+	Hs
		259261 UBC_HUMAN (1-685): 0: 846: 100.00		UBP12_HUMAN (178-559): 4.46e-110: 335: 23.12
+	Hs
		475765 UBC_HUMAN (1-685): 0: 846: 100.00		UBP10_HUMAN (16-559): 5.8e-104: 332: 17.07
+	Hs
		475932 UBC_HUMAN (1-685): 0: 846: 100.00		U17L2_HUMAN (149-563): 2.22e-106: 331: 24.40
+	Hs
		476658 UBC_HUMAN (1-685): 0: 846: 100.00		UBP3_HUMAN (172-561): 1.99e-106: 331: 28.61
+	Dm
		477538 UBIQP_DROME (1-610): 0: 752: 99.84		NOT_DROME (184-557): 3.28e-107: 332: 25.53
+	Hs
		475693 UBC_HUMAN (1-685): 0: 846: 100.00		UBP4_HUMAN (414-556): 5.2e-25: 112: 39.73
+	Hs
		476624 UBC_HUMAN (1-685): 0: 846: 100.00		UBP15_HUMAN (405-556): 3.29e-25: 112: 41.29
+	At
		1210479 UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80		UBP15_ARATH (12-563): 5.66e-118: 372: 20.77
+	Sc
		477294 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP5_YEAST (92-558): 1.68e-102: 329: 24.72
+	Sc
		477366 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP8_YEAST (210-559): 9.06e-100: 312: 26.47
+	At
		1092065 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBP15_ARATH (12-563): 5.66e-118: 372: 20.77
+	Mm
		476865 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP8_MOUSE (5-561): 3.7e-128: 403: 26.47
+	Mm
		476741 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP46_MOUSE (197-558): 1.8e-110: 336: 23.81
+	Mm
		476695 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP4_MOUSE (391-556): 3.03e-26: 115: 39.05