HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: AGO2 (Q9UKV8)
Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
Gene: AGO2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.641

Property	Details
Experiments	28190767, 16196087, 17932509
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 859
+	Hs
		476555 UBC_HUMAN (1-685): 0: 846: 100.00		AGO1_HUMAN (17-859): 0: 1182: 83.16
+	Hs
		476398 UBC_HUMAN (1-685): 0: 846: 100.00		AGO3_HUMAN (5-859): 0: 1165: 79.75
+	At
		138332 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		AGO1_ARATH (3-858): 0: 1096: 41.16
+	At
		1092433 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		AGO10_ARATH (25-858): 0: 1048: 41.48
+	At
		1092341 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		AGO5_ARATH (16-858): 0: 1000: 39.91
+	At
		1092324 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		AGO2_ARATH (13-858): 0: 846: 29.98